Serum HBV RNA is a Potential Predictor of Hepatitis B Surface Antigen Reversion.

Serum HBV RNA is a Potential Predictor of Hepatitis B Surface Antigen Reversion.
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血清 HBV RNA 是乙型肝炎表面抗原逆转的潜在预测因子

DOI:
10.1002/hep4.1249
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发表时间:
2018-10
影响因子:
5.1
通讯作者:
Lu F
Lu F
中科院分区:
医学2区
文献类型:
--
作者:
Wang J;Chen X;Wu Y;Cao Z;Wang L;Huang H;Chen X;Lu F

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Because sustained hepatitis B surface antigen (HBsAg) seroclearance with or without anti-HB appearance represents a functional cure of chronic hepatitis B (CHB), HBsAg loss has been recommended as an optimal endpoint of antiviral treatment.(1) However, composite reversion including HBsAg reversion and/or hepatitis B virus (HBV) DNA reappearance may still occur after drug withdrawal, even after achieving HBsAg loss.(2) Therefore, a novel marker predicting the risk of composite reversion is needed. Because serum HBV RNA has been suggested as a potential predictor of nucleos(t)ide analogue (NA) off-therapy viral rebound in our previous study,(3) we wondered whether it could be used to predict the risk of composite reversion. (Hepatology Communications 2018;2:1168-1171).
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