Prefrontal Plasticity and Stress Inoculation-Induced Resilience
Prefrontal Plasticity and Stress Inoculation-Induced Resilience
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DOI：
10.1159/000216540
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发表时间：
2009-01-01
影响因子：
2.9
通讯作者：
Lyons, David M.
中科院分区：
文献类型：
--
作者：
Katz, Maor;Liu, Chunlei;Lyons, David M.
应对轻微的早期生活压力往往会使随后的应对努力更加有效，因此更有可能被用作唤醒调节和恢复能力的一种手段。在这里，我们展示了这种类似发育学习的应激接种过程增加了青春期周围猴的腹内侧前额叶皮质体积。更大的体积并不反映皮质厚度的增加，相反，它代表着腹内侧额前皮质的表面积扩大。弥散张量磁共振成像显示，前额叶腹内侧皮质的扩张与脑白质髓鞘形成的增加相吻合。这些发现表明，应对早期生活压力的过程增加了前额叶髓鞘形成，并扩大了广泛控制觉醒调节和弹性的皮质区域。版权所有(C)2009 S.Karger AG，巴塞尔
Coping with mild early life stress tends to make subsequent coping efforts more effective and therefore more likely to be used as a means of arousal regulation and resilience. Here we show that this developmental learning-like process of stress inoculation increases ventromedial prefrontal cortical volumes in peripubertal monkeys. Larger volumes do not reflect increased cortical thickness but instead represent surface area expansion of ventromedial prefrontal cortex. Expansion of ventromedial prefrontal cortex coincides with increased white matter myelination inferred from diffusion tensor magnetic resonance imaging. These findings suggest that the process of coping with early life stress increases prefrontal myelination and expands a region of cortex that broadly controls arousal regulation and resilience. Copyright (C) 2009 S. Karger AG, Basel