Prognostic value of epidermal growth factor receptor in patients with gastric cancer: A meta-analysis
Prognostic value of epidermal growth factor receptor in patients with gastric cancer: A meta-analysis
复制标题
表皮生长因子受体对胃癌患者预后价值的荟萃分析
DOI：
10.1016/j.gene.2013.07.106
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发表时间：
2013-10-15
期刊：
影响因子：
3.5
通讯作者：
Zhao, Qingchuan
中科院分区：
文献类型：
--
作者：
Hong, Liu;Han, Yu;Zhao, Qingchuan
背景：表皮生长因子受体（EGFR）在胃癌的发生发展中起重要作用。方法：采用Meta分析方法，检索科克伦图书馆、PubMed、EMBASE和Science Direct数据库1970年1月至2013年5月的相关文献，分析EGFR在胃癌患者预后中的价值。数据提取自评估EGFR表达阳性或阴性的胃癌患者生存率的研究。结果：共纳入5个研究的1600例胃癌患者，均进行了最终分析。EGFR阳性表达者与阴性表达者术后生存率的HR为1.16（95% CI：0.94-1.43），EGFR阳性表达与胃癌患者术后生存率无显著相关性。(C)2013 Elsevier B. V.保留所有权利。
Background: The epidermal growth factor receptor (EGFR) plays important roles in the development of gastric cancer. This study aims to analyze the prognostic value of EGFR in patients with gastric cancer.Methods: A meta-analysis is performed by searching Cochrane Library, PubMed, EMBASE and Science Direct databases from Jan 1970 to May 2013. Data are extracted from studies evaluating the survival of gastric cancer patients with either positive or negative EGFR expression. Pooled hazard ratios (HRs) and 95% confidence intervals (Cls) are calculated.Results: Totally 1600 cases of gastric cancer patients from five studies are subjected to final analysis. The HR of post-operational survival of patients with positive EGFR expression is 1.16 (95% CI: 0.94-1.43) as compared with those with negative expression, indicating that positive EGFR expression does not significantly predict the poor survival of gastric cancer.Conclusions: EGFR expression is not an independent predictor for the survival of gastric cancer patients. (C) 2013 Elsevier B.V. All rights reserved.