Perceived versus proven SARS-CoV-2-specific immune responses in health-care professionals
Perceived versus proven SARS-CoV-2-specific immune responses in health-care professionals
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DOI：
10.1007/s15010-020-01461-0
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发表时间：
2020-06-10
期刊：
影响因子：
7.5
通讯作者：
Jablonka, Alexandra
中科院分区：
文献类型：
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作者：
Behrens, Georg M. N.;Cossmann, Anne;Jablonka, Alexandra
人们一直担心医疗系统中存在大量迄今为止未被诊断出的新冠病毒（SARS-CoV - 2）感染病例。新冠接触（CoCo）研究对一所大学医院的217名一线医护人员进行每周一次的新冠病毒特异性血清学检测（IgA/IgG）。研究参与者估计自己感染新冠病毒的个人可能性平均为21%[中位数为15%，四分位间距（IQR）为5 - 30%]。相比之下，基线时抗新冠病毒IgG的患病率约为1 - 2%。从长远来看，对医护人员进行定期的抗新冠病毒IgG检测可能有助于合理分配防护措施资源以及对新冠患者的护理资源。
There have been concerns about high rates of thus far undiagnosed SARS-CoV-2 infections in the health-care system. The COVID-19 Contact (CoCo) Study follows 217 frontline health-care professionals at a university hospital with weekly SARS-CoV-2-specific serology (IgA/IgG). Study participants estimated their personal likelihood of having had a SARS-CoV-2 infection with a mean of 21% [median 15%, interquartile range (IQR) 5-30%]. In contrast, anti-SARS-CoV-2 IgG prevalence was about 1-2% at baseline. Regular anti-SARS-CoV-2 IgG testing of health-care professionals may aid in directing resources for protective measures and care of COVID-19 patients in the long run.