Fhx (Foxj2) expression is activated during spermatogenesis and very early in embryonic development
Fhx (Foxj2) expression is activated during spermatogenesis and very early in embryonic development
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DOI：
10.1016/s0925-4773(00)00410-x
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发表时间：
2000-10-01
影响因子：
2.6
通讯作者：
Rey-Campos, J
中科院分区：
文献类型：
--
作者：
Granadino, B;Arias-de-la-Fuente, C;Rey-Campos, J
FHX (FOXJ2) 是一种最近鉴定的人类叉头转录激活剂，它以双序列特异性结合 DNA。我们克隆了小鼠直系同源物 Foxj2 的 cDNA，并表征了其在性腺中以及小鼠早期植入前发育过程中的表达。在睾丸中，Foxj2 从粗线期精母细胞到圆形精子细胞表达，但在精原细胞中不表达。除生殖谱系外，仅睾丸的支持细胞显示 Foxj2 表达。在卵巢中，只有卵泡的颗粒细胞表达该因子。成熟的精子和卵母细胞均未表现出 Foxj2 的表达。 Foxj2 表达在合子发育早期被激活，早在 8 细胞阶段胚胎时就被检测到。囊胚的两个细胞层：滋养外胚层 (TE) 和内细胞团 (ICM) 均表达 Foxj2。 (C) 2000 Elsevier Science Ireland Ltd. 保留所有权利。
FHX (FOXJ2) is a recently characterized human fork head transcriptional activator that binds DNA with a dual sequence specificity. We have cloned the cDNA for the mouse orthologue Foxj2 and characterized its expression in the gonads and along the early pre-implantation development of the mouse. In the testis, Foxj2 is expressed from pachytene spermatocytes to round spermatids, but not in spermatogonia. In addition to the germ lineage, only Sertoli cells of the testis showed expression of Foxj2. In the ovary, only granulosa cells of the follicles express the factor. Neither mature spermatozoa nor oocytes showed expression of Foxj2. Foxj2 expression is early activated in zygotic development, being detected since as early as 8-cell stage embryos. Both cell layers of the blastocyst: the trophectoderm (TE) and the inner cell mass (ICM), express Foxj2. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.