Human and mouse trigeminal ganglia cell atlas implicates multiple cell types in migraine.
Human and mouse trigeminal ganglia cell atlas implicates multiple cell types in migraine.
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DOI：
10.1016/j.neuron.2022.03.003
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发表时间：
2022-06-01
期刊：
影响因子：
16.2
通讯作者：
Renthal, William
中科院分区：
文献类型：
--
作者：
Yang, Lite;Xu, Mengyi;Bhuiyan, Shamsuddin A.;Li, Jia;Zhao, Jun;Cohrs, Randall J.;Susterich, Justin T.;Signorelli, Sylvia;Green, Ursula;Stone, James R.;Levy, Dan;Lennerz, Jochen K.;Renthal, William
三叉神经节神经元的敏化导致原发性头痛疾病，如偏头痛，但涉及的特定神经元和非神经元三叉神经亚型仍不清楚。因此，我们开发了一个细胞图谱，其中以单细胞分辨率对人类和小鼠三叉神经节进行了转录和表观基因组分析。这些数据描述了每个三叉神经节细胞类型内进化上保守的和人类特异性的基因表达模式，以及有助于细胞类型特异性基因表达的转录因子和基因调控元件。然后，我们利用这些数据来识别与偏头痛相关的人类遗传变异和两种头痛小鼠模型有关的三叉神经节细胞类型。这个三叉神经节细胞图谱提高了我们对头痛病理生理学所涉及的细胞类型、基因和表观基因组特征的理解，并建立了丰富的细胞类型特异性分子特征资源，以指导开发更具选择性的头痛和面部疼痛治疗方法。三叉神经节神经元在偏头痛和相关头痛疾病中被激活。Yang等人开发了一种细胞图谱，其中以单细胞分辨率对人类和小鼠三叉神经节进行转录和表观基因组分析。这些数据为了解偏头痛易感性的细胞类型和遗传机制以及开发新型镇痛药提供了丰富的资源。
Sensitization of trigeminal ganglion neurons contributes to primary headache disorders such as migraine, but the specific neuronal and non-neuronal trigeminal subtypes that are involved remain unclear. We thus developed a cell atlas in which human and mouse trigeminal ganglia are transcriptionally and epigenomically profiled at single-cell resolution. These data describe evolutionarily conserved and human-specific gene expression patterns within each trigeminal ganglion cell type, as well as the transcription factors and gene regulatory elements that contribute to cell-type-specific gene expression. We then leveraged these data to identify trigeminal ganglion cell types that are implicated both by human genetic variation associated with migraine and two mouse models of headache. This trigeminal ganglion cell atlas improves our understanding of the cell types, genes, and epigenomic features involved in headache pathophysiology and establishes a rich resource of cell-type-specific molecular features to guide the development of more selective treatments for headache and facial pain. Trigeminal ganglion neurons are activated in migraine and related headache disorders. Yang et al. developed a cell atlas in which human and mouse trigeminal ganglia are transcriptionally and epigenomically profiled at single-cell resolution. These data provide a rich resource for understanding the cell types and genetic mechanisms underlying migraine susceptibility and for developing novel analgesics.
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影响因子：
30.8
作者：
Fulco, Charles P.;Nasser, Joseph;Engreitz, Jesse M.
通讯作者：
Engreitz, Jesse M.
影响因子：
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作者：
Gormley, Padhraig;Anttila, Verneri;Palotie, Aarno
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单细胞染色质可及性揭示了调节变化的原理。
影响因子：
64.8
作者：
Buenrostro JD;Wu B;Litzenburger UM;Ruff D;Gonzales ML;Snyder MP;Chang HY;Greenleaf WJ
通讯作者：
Greenleaf WJ
影响因子：
11.2
作者：
DeFelice, Milena;Eyde, Nathan;Dodick, David;Dussor, Gregory O.;Ossipov, Michael H.;Fields, Howard L.;Porreca, Frank
通讯作者：
Porreca, Frank
DOI：
10.1126/science.abf9277
发表时间：
2021-07-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Brioschi S;Wang WL;Peng V;Wang M;Shchukina I;Greenberg ZJ;Bando JK;Jaeger N;Czepielewski RS;Swain A;Mogilenko DA;Beatty WL;Bayguinov P;Fitzpatrick JAJ;Schuettpelz LG;Fronick CC;Smirnov I;Kipnis J;Shapiro VS;Wu GF;Gilfillan S;Cella M;Artyomov MN;Kleinstein SH;Colonna M
通讯作者：
Colonna M