Evidence for the presence of two Homer 1 transcripts in skeletal and cardiac muscles
Evidence for the presence of two Homer 1 transcripts in skeletal and cardiac muscles
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DOI：
10.1006/bbrc.2000.3948
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发表时间：
2000-12-20
影响因子：
3.1
通讯作者：
Volpe, P
中科院分区：
文献类型：
--
作者：
Sandonà, D;Tibaldo, E;Volpe, P
最近在神经元中描述了参与信号转导的活性依赖性控制的蛋白质家族Homer 1、2和3 [Xiao，B.，图角，澳-地J.，彼得拉利亚河美国，Yuan，J. P.，Dean，A.，布雷德角D、Ruggiero，A.，Lanahan，A.一、温特霍尔德河J.，和Worley，P. F.（1998）荷马调节组1代谢型谷氨酸受体与荷马相关突触蛋白的多价复合物的关联。Neuron 21，107-716]。通过RT-PCR和RNasePA，在大鼠的骨骼肌和心肌中检测到Homer 1a和Homer 1c的mRNA转录物，但未检测到Homer 1b。Homer 1a和Homer 1c cDNA的全长克隆已经完成：通过比较骨骼肌、心肌和小脑，没有组织特异性，通过比较大鼠和小鼠序列，有一些种属特异性碱基替换。通过Homer 1亚型组成的转变施加的调节机制可能在横纹肌中起作用。(C)北京大学出版社.
A family of proteins, Homers 1, 2 and 3, involved in activity-dependent control of signal transduction has been recently described in neurons [Xiao, B., Tu, C. J., Petralia, R. S., Yuan, J. P., Dean, A., Breder, C. D., Ruggiero, A., Lanahan, A. A., Wenthold, R. J., and Worley, P. F. (1998) Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of Homer-related, synaptic proteins. Neuron 21, 107-716]. By RT-PCR and RNasePA, mRNAs transcripts for Homer la and Homer 1c, but not Homer 1b, are detected in both skeletal and cardiac muscles of the rat. Full-length cloning of Homer 1a and Homer 1c cDNAs has been accomplished: There is no tissue specificity, by comparing skeletal muscle, cardiac muscle and cerebellum, and there are a few species-specific base substitutions, by comparing rat and mouse sequences. The regulatory mechanism exerted via transition of Homer 1 isoform composition may be operative in striated muscles. (C) 2000 Academic Press.