"Targeting astrocytes in CNS injury and disease: A translational research approach".
"Targeting astrocytes in CNS injury and disease: A translational research approach".
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DOI：
10.1016/j.pneurobio.2016.03.009
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发表时间：
2016-09
影响因子：
6.7
通讯作者：
Silver J
中科院分区：
文献类型：
--
作者：
Filous AR;Silver J
星形胶质细胞是中枢神经系统的主要组成部分。这些胶质细胞在调节血脑屏障功能、突触的形成和维持、谷氨酸摄取以及对周围神经元和胶质细胞的营养支持中起主要作用。因此，维持这些细胞的正常功能对生存至关重要。星形胶质细胞缺陷与从神经退行性疾病到神经胶质瘤的各种神经病理损伤相关。此外，CNS损伤会导致星形胶质细胞发生剧烈变化，通常导致称为反应性星形胶质细胞增生的现象。这个过程对于保护周围健康组织免受损伤扩散非常重要，同时它也抑制轴突再生和可塑性。在这里，我们讨论了星形胶质细胞在损伤后和疾病中的重要作用，以及恢复星形胶质细胞正常功能的潜在治疗方法。
Astrocytes are a major constituent of the central nervous system. These glia play a major role in regulating blood-brain barrier function, the formation and maintenance of synapses, glutamate uptake, and trophic support for surrounding neurons and glia. Therefore, maintaining the proper functioning of these cells is crucial to survival. Astrocyte defects are associated with a wide variety of neuropathological insults, ranging from neurodegenerative diseases to gliomas. Additionally, injury to the CNS causes drastic changes to astrocytes, often leading to a phenomenon known as reactive astrogliosis. This process is important for protecting the surrounding healthy tissue from the spread of injury, while it also inhibits axonal regeneration and plasticity. Here, we discuss the important roles of astrocytes after injury and in disease, as well as potential therapeutic approaches to restore proper astrocyte functioning.