EFFECTS OF PHYSICAL PARAMETERS ON HIGH-TEMPERATURE ULTRASOUND HYPERTHERMIA
EFFECTS OF PHYSICAL PARAMETERS ON HIGH-TEMPERATURE ULTRASOUND HYPERTHERMIA
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DOI：
10.1016/0301-5629(90)90070-s
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发表时间：
1990-01-01
影响因子：
2.9
通讯作者：
ROEMER, RB
中科院分区：
文献类型：
--
作者：
BILLARD, BE;HYNYNEN, K;ROEMER, RB
本研究的目的是探讨利用高功率超声脉冲诱导灌注无关的、可预测的治疗热剂量的可行性。使用计算机模拟研究血液灌注、组织特性、换能器特性和治疗几何形状对由短超声脉冲输送的温升和热剂量的影响。在体外和体内进行实验，以研究血液灌注变化的影响。结果表明，短脉冲长度（≤ 0.001）是一个很好的选择。2s）和小的焦点直径（约3mm）给出了几乎与灌注无关的温度升高和热剂量。组织特性的正常波动不应对治疗产生显著影响，前提是为每个单独应用选择适当的换能器。
The purpose of this research was to investigate the feasibility of inducing perfusion independent, predictable therapeutic thermal dose using high power ultrasonic pulses. Computer simulations were used to study the effects of blood perfusion, tissue properties, transducer characteristics, and treatment geometry on the temperature elevation and thermal dose delivered by short ultrasonic pulses. Experiments were conducted in vitro and in vivo to investigate the effects of blood perfusion changes. Results show that short pulse lengths (.ltoreq. 2 s) and small focal diameters (.apprx.3 mm) give temperature elevations and thermal doses which are nearly perfusion independent. Normal fluctuations in tissue properties should not have a significant effect on the treatment provided that proper choice of transducer is made for each individual application.