NOVEL NEURONAL PROTEOLIPID PROTEIN ISOFORMS ENCODED BY THE HUMAN MYELIN PROTEOLIPID PROTEIN 1 GENE
NOVEL NEURONAL PROTEOLIPID PROTEIN ISOFORMS ENCODED BY THE HUMAN MYELIN PROTEOLIPID PROTEIN 1 GENE
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DOI：
10.1016/j.neuroscience.2009.12.047
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发表时间：
2010-03-17
期刊：
影响因子：
3.3
通讯作者：
Vaurs-Barriere, C.
中科院分区：
文献类型：
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作者：
Sarret, C.;Combes, P.;Vaurs-Barriere, C.
人类髓鞘蛋白脂蛋白1基因(HPLP1)编码中枢神经系统(CNS)的主要髓鞘结构蛋白，经典的描述是表达于少突胶质细胞，即CNS髓鞘细胞。我们在hPLP1基因的内含子1中发现了两个新的外显子，这两个外显子导致了额外的mRNA和蛋白亚型的表达，这些亚型主要在神经元中表达，而不是在少突胶质细胞中表达。这些新的神经元PLP亚型在人类胚胎发育时就被检测到，并且它们的伴随表达是人类特有的。与经典的PLP蛋白一样，新的蛋白亚型似乎是针对质膜的。这些结果首次表明，PLP在人类中可能不仅在少突胶质细胞中具有功能，而且在神经元中也具有功能，并可能与轴突-神经胶质通讯有关。此外，hPLP1基因的这种神经元表达可能解释了携带hPLP1基因突变的患者的神经元功能障碍。(C)2010年IBRO。爱思唯尔有限公司出版。保留所有权利。
The human myelin proteolipid protein 1 gene (hPLP1), which encodes the major structural myelin proteins of the central nervous system (CNS), is classically described as expressed in the oligodendrocytes, the CNS myelinating cells. We identified two new exons in the intron 1 of the hPLP1 gene that lead to the expression of additional mRNA and protein isoforms mainly expressed in neurons instead of oligodendrocytes. Those novel neuronal PLP isoforms are detected as soon as human fetal development and their concomitant expression is specific of the human species. As classical PLP proteins, the novel protein isoforms seem to be addressed to the plasma membrane. These results suggest for the first time that PLP may have functions in humans not only in oligodendrocytes but also in neurons and could be implicated in axono-glial communication. Moreover, this neuronal expression of the hPLP1 gene might explain the neuronal dysfunctions in patients carrying hPLP1 gene mutations. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.