ABNORMAL B-LYMPHOCYTE DEVELOPMENT, ACTIVATION, AND DIFFERENTIATION IN MICE THAT LACK OR OVEREXPRESS THE CD19 SIGNAL-TRANSDUCTION MOLECULE
ABNORMAL B-LYMPHOCYTE DEVELOPMENT, ACTIVATION, AND DIFFERENTIATION IN MICE THAT LACK OR OVEREXPRESS THE CD19 SIGNAL-TRANSDUCTION MOLECULE
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DOI：
10.1016/1074-7613(95)90157-4
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发表时间：
1995-07-01
期刊：
影响因子：
32.4
通讯作者：
TEDDER, TF
中科院分区：
文献类型：
--
作者：
ENGEL, P;ZHOU, LJ;TEDDER, TF
产生CD 19缺陷小鼠以检查CD 19在体内B细胞生长调节中的作用。CD 19的缺失对骨髓中B细胞的生成没有有害影响，但外周淋巴组织中B细胞的数量显著减少。CD19缺陷小鼠的B细胞对有丝分裂原的增殖反应明显降低，血清免疫球蛋白水平也明显降低。相反，过表达CD 19的小鼠在骨髓中的早期B细胞发育中有显著缺陷，增强了促有丝分裂反应，并增加了血清免疫球蛋白水平。这些实验表明，CD 19的功能是确定细胞表面受体的信号传导阈值，这些受体调节B淋巴细胞的选择、活化和分化。
CD19-deficient mice were generated to examine the role of CD19 in B cell growth regulation in vivo. Deletion of CD19 had no deleterious effects on the generation of B cells in the bone marrow, but there was a significant reduction in the number of B cells in peripheral lymphoid tissues. B cells from CD19-deficient mice exhibited markedly decreased proliferative responses to mitogens, and serum immunoglobulin levels were also significantly decreased. In contrast, mice that overexpressed CD19 had significant defects in early B cell development in the bone marrow, augmented mitogenic responses, and increased serum immunoglobulin levels. These experiments indicate that CD19 functions to define signaling thresholds for cell surface receptors that regulate B lymphocyte selection, activation, and differentiation.