Depression of LTP in rat dentate gyrus by naloxone is reversed by GABAA blockade.
Depression of LTP in rat dentate gyrus by naloxone is reversed by GABAA blockade.
复制标题
GABAA 阻断可逆转纳洛酮对大鼠齿状回 LTP 的抑制作用。
DOI：
10.1016/0006-8993(95)00510-w
复制
发表时间：
1995
期刊：
影响因子：
2.9
通讯作者：
Lewis,DV
中科院分区：
文献类型：
--
作者：
Xie,CW;Lewis,DV
Long-term potentiation (LTP) of the lateral perforant path (LPP) to dentate granule cell (DGC) synapse is suppressed by the opioid antagonist, naloxone, and thus appears to be dependent upon the release of endogenous opioids from the LPP. It has been suggested that endogenous opioids enhance LTP by depressing GABAAinhibition. As one test of this hypothesis, we determined whether blockade of GABAAinhibition would alleviate the naloxone block of LTP in the LPP. Consistent with the hypothesis that endogenous opioids enable LTP by disinhibition of the DGCs, naloxone no longer blocked LTP in the presence of the GABAAantagonist, bicuculline methiodide. Futhermore, although blockade of μ receptors suppressed LTP of the slope of the population excitatory potential (pEPSP), blockade of both μ and δ opioid receptors was needed to suppress LTP of both the pEPSP and the orthodromic population spike (OPS).
