Role of purinergic receptors in cardiac sympathetic nerve injury in diabetes mellitus
Role of purinergic receptors in cardiac sympathetic nerve injury in diabetes mellitus
复制标题
嘌呤能受体在糖尿病心脏交感神经损伤中的作用
DOI：
10.1016/j.neuropharm.2022.109406
复制
发表时间：
2023-01-09
影响因子：
4.7
通讯作者：
Li，Guilin
中科院分区：
文献类型：
--
作者：
Hu，Qixing;Li，Guilin
糖尿病心脏自主神经病变是糖尿病常见而严重的慢性并发症，可导致交感神经和副交感神经失衡，交感神经相对兴奋。嘌呤能受体在这一过程中起着至关重要的作用。糖尿病心脏交感神经损伤影响嘌呤能受体的表达，激活的嘌呤能受体影响不同信号通路的磷酸化和炎症过程的调节。本文介绍了糖尿病时交感神经的异常改变，并对最近发表的几种嘌呤能受体亚型在糖尿病心脏交感神经损伤中作用的研究进行了综述。这些研究表明嘌呤能受体作为新的药物靶点对糖尿病自主神经病变的治疗具有重要意义。本文是“嘌呤能信号传导：50年”特刊的一部分。
Diabetic cardiac autonomic neuropathy is a common and serious chronic complication of diabetes, which can lead to sympathetic and parasympathetic nerve imbalance and a relative excitation of the sympathetic nerve. Purinergic receptors play a crucial role in this process. Diabetic cardiac sympathetic nerve injury affects the expression of purinergic receptors, and activated purinergic receptors affect the phosphorylation of different signaling pathways and the regulation of inflammatory processes. This paper introduces the abnormal changes of sympathetic nerve in diabetes mellitus and summarizes the recently published studies on the role of several purinergic receptor subtypes in diabetic cardiac sympathetic nerve injury. These studies suggest that purinergic receptors as novel drug targets are of great significance for the treatment of diabetic autonomic neuropathy.This article is part of the Special Issue on “Purinergic Signaling: 50 years”.