In vivo evaluation of a Ti-based bulk metallic glass alloy bar
In vivo evaluation of a Ti-based bulk metallic glass alloy bar
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DOI：
10.3233/bme-151546
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发表时间：
2015-01-01
影响因子：
1
通讯作者：
Takakuda, Kazuo
中科院分区：
文献类型：
--
作者：
Kokubun, Ryo;Wang, Wei;Takakuda, Kazuo
钛基大块非晶合金具有高强度、低弹性模量和高耐腐蚀性，在生物医学领域具有潜在的应用前景。然而，尚未对其生物相容性进行全面的体内评价。本研究将钛基大块金属玻璃棒植入大鼠股骨内，跟踪观察局部组织反应及其成分离子在局部和全身的扩散情况。Ti基BMG（Ti40Zr10Cu34Pd14Sn2）合金具有高强度和高弹性的优良特性。体内植入物评价表明，其具有良好的组织相容性，与钛样品具有等同的骨整合和结合能力。植入后3个月内未检测到组分离子扩散。证实了其用于骨植入的可能性和有效性。因此，建议进行进一步的长期植入研究。
Ti-based bulk metallic glasses are reported with high strength, low Young modulus and high corrosion resistance, suggesting their potentials in biomedical applications. However a thorough in vivo evaluation of its biocompatibilities has not been conducted yet. In this study, we implanted bars of Ti-based bulk metallic glass in the femoral bone of rats, followed up local tissue reaction as well as its component ions' diffusion in local area and whole body. The Ti-based BMG (Ti40Zr10Cu34Pd14Sn2) alloy exhibited favorable features of both high strength and high elasticity. In vivo implant evaluation showed that it has a good tissue compatibility, equivalent bone integration and bonding ability with Ti sample. No component ion diffusion was detected up to 3 months post implantation. The possibility and efficacy of its use for bone implant is confirmed. Thus further long term implant study is recommended.