Common genetic vulnerability for nicotine and alcohol dependence in men
Common genetic vulnerability for nicotine and alcohol dependence in men
复制标题
DOI：
10.1001/archpsyc.56.7.655
复制
发表时间：
1999-07-01
影响因子：
--
通讯作者：
Tsuang, M
中科院分区：
文献类型：
--
作者：
True, WR;Xian, H;Tsuang, M
背景：尼古丁和酒精依赖经常同时发生。我们检查了来自男性双胞胎的数据，以确定尼古丁和酒精依赖是否有共同的遗传或环境影响，如果有的话，估计这些影响的程度和相关性。方法：研究对象为3356名越南时代双胞胎登记处的男性-男性双胞胎成员，他们参加了1992年第3版修订诊断访谈计划的电话管理。进行遗传模型拟合，以估计遗传和环境对终生尼古丁和酒精依赖的影响程度和相关性。结果：烟碱依赖遗传率为60.3%(95%可信区间[CI]， 55.4% ~ 65.2%)；酒精依赖，55.1% （95% CI, 49.7%-60.5%）。终身尼古丁和酒精依赖共存的最佳拟合模型包括两种疾病之间存在显著的遗传相关性（r = 0.68; 95% CI, 0.61-0.74）和适度的独特环境相关性（r = 0.23; 95% CI, 0.14-0.32）。结论：这些数据表明男性对尼古丁和酒精依赖有共同的遗传易感性。这种共同的遗传影响可以部分解释临床和流行病学观察结果，即酗酒者往往依赖于吸烟者。
Background: Nicotine and alcohol dependence often occur together. We examined data from male twin pairs to determine whether there are genetic or environmental influences common to nicotine and alcohol dependence, and, if so, to estimate the magnitude and correlation of these influences.Methods: Subjects were 3356 male-male twin-pair members of the Vietnam Era Twin Registry who participated in a 1992 telephone administration of the Diagnostic Interview Schedule Version 3 Revised. Genetic model fitting was performed to estimate the magnitude and correlation of genetic and environmental contributions to lifetime nicotine and alcohol dependence.Results: The heritability of nicotine dependence was 60.3% (95% confidence interval [CI], 55.4%-65.2%); that of alcohol dependence, 55.1% (95% CI, 49.7%-60.5%). The best-fitting model for the co-occurrence of lifetime nicotine and alcohol dependence included a substantial genetic correlation between both disorders (r = 0.68; 95% CI, 0.61-0.74) and a modest unique environmental correlation (r = 0.23; 95% CI, 0.14-0.32).Conclusions: These data suggest a common genetic vulnerability to nicotine and alcohol dependence in men. This common genetic influence may partially explain the clinical and epidemiological observations that alcoholics are often dependent smokers.