Candida albicans biofilms and polymicrobial interactions.
Candida albicans biofilms and polymicrobial interactions.
复制标题
白色念珠菌生物膜及多微生物相互作用
DOI：
10.1080/1040841x.2020.1843400
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发表时间：
2021-03
影响因子：
6.5
通讯作者：
Richardson JP
中科院分区：
文献类型：
--
作者：
Ponde NO;Lortal L;Ramage G;Naglik JR;Richardson JP
白色念珠菌是人类微生物群中一种常见的真菌。在健康个体中，它通常是一种无害的共生菌，但有若干因素可导致其过度生长，并在宿主体内引发一系列并发症，从局部浅表感染到全身性的、危及生命的播散性念珠菌病。白色念珠菌的一个主要毒力因子是其形成生物膜的能力，生物膜是一种细胞紧密聚集的群落，能够在非生物和生物基质上生长，包括植入的医疗器械和黏膜表面。这些生物膜极难根除，对常规抗真菌治疗有抵抗力，并且与高发病率和高死亡率相关，这使得与生物膜相关的感染成为一项重大的临床挑战。在此，我们综述了目前关于白色念珠菌生物膜形成和发育过程的知识，包括黏附、细胞外基质产生以及调节生物膜发育的转录网络等核心过程。我们还考虑了生物膜生活方式的优势，并探讨了由白色念珠菌和特定微生物种类形成的多物种生物膜内的多种微生物相互作用。
Candida albicans is a common fungus of the human microbiota. While generally a harmless commensal in healthy individuals, several factors can lead to its overgrowth and cause a range of complications within the host, from localised superficial infections to systemic life-threatening disseminated candidiasis. A major virulence factor of Candida albicans is its ability to form biofilms, a closely packed community of cells that can grow on both abiotic and biotic substrates, including implanted medical devices and mucosal surfaces. These biofilms are extremely hard to eradicate, are resistant to conventional antifungal treatment and are associated with high morbidity and mortality rates, making biofilm associated infections a major clinical challenge. Here, we review the current knowledge of the processes involved in Candida albicans biofilm formation and development, including the central processes of adhesion, extracellular matrix production and the transcriptional network that regulates biofilm development. We also consider the advantages of the biofilm lifestyle and explore polymicrobial interactions within multispecies biofilms that are formed by Candida albicans and selected microbial species.
影响因子：
4.6
作者：
Rouabhia M;Semlali A;Chandra J;Mukherjee P;Chmielewski W;Ghannoum MA
通讯作者：
Ghannoum MA