The lens in focus: a comparison of lens development in Drosophila and vertebrates.
The lens in focus: a comparison of lens development in Drosophila and vertebrates.
复制标题
焦点的镜头：果蝇和脊椎动物的晶状体发育的比较。
DOI：
10.1007/s00438-011-0643-y
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发表时间：
2011-10
期刊：
影响因子：
--
通讯作者：
Cook TA
中科院分区：
文献类型：
--
作者：
Charlton-Perkins M;Brown NL;Cook TA
几个世纪以来，眼睛的进化一直是研究的主要课题。分子遗传学的出现提供了一个令人惊讶的发现，即形态上不同的眼睛依赖于保守的调控基因网络的形成。虽然其中许多进展往往源于对果蝇复眼的研究，后来转化为脊椎动物系统的发现，但对脊椎动物晶状体发育的研究远远超过果蝇的研究。这可能很大程度上是历史性的，因为斯佩曼和曼戈尔德的组织诱导范例是在两栖动物晶状体中发现的。最近对果蝇晶状体发育的研究已经开始定义与脊椎动物晶状体的分子共性。在这里，我们概述了果蝇晶状体的发育，讨论了控制晶状体细胞规格和分化的内在和外在因素。然后，我们总结了脊椎动物晶状体发育中的关键形态和分子事件，强调与这两个系统密切相关的调节因素和网络。最后，我们提供了一个比较分析，重点介绍了有助于进一步阐明无脊椎动物和脊椎动物屈光系统形成之间的保守程度的研究领域。
The evolution of the eye has been a major subject of study dating back centuries. The advent of molecular genetics offered the surprising finding that morphologically distinct eyes rely on conserved regulatory gene networks for their formation. While many of these advances often stemmed from studies of the compound eye of the fruit fly, Drosophila melanogaster, and later translated to discoveries in vertebrate systems, studies on vertebrate lens development far outnumber those in Drosophila. This may be largely historical, since Spemann and Mangold’s paradigm of tissue induction was discovered in the amphibian lens. Recent studies on lens development in Drosophila have begun to define molecular commonalities with the vertebrate lens. Here, we provide an overview of Drosophila lens development, discussing intrinsic and extrinsic factors controlling lens cell specification and differentiation. We then summarize key morphological and molecular events in vertebrate lens development, emphasizing regulatory factors and networks strongly associated with both systems. Finally, we provide a comparative analysis that highlights areas of research that would help further clarify the degree of conservation between the formation of dioptric systems in invertebrates and vertebrates.