Hair Regeneration Treatment Using Adipose-Derived Stem Cell Conditioned Medium: Follow-up With Trichograms
Hair Regeneration Treatment Using Adipose-Derived Stem Cell Conditioned Medium: Follow-up With Trichograms
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发表时间：
2015-03
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通讯作者：
H. Fukuoka;H. Suga
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作者：
H. Fukuoka;H. Suga
目的：脂肪干细胞分泌多种生长因子，促进毛发生长。这项研究考察了脂肪干细胞条件培养液对脱发的影响。方法：对22例脱发患者(男11例，女11例)皮内注射脂肪干细胞条件培养液。患者每3-5周接受一次治疗，共6次。治疗前和治疗后用三叉图计数毛发数量。10名患者(8名男性和2名女性)也进行了半侧对照研究。结果：治疗后男性患者(包括未服用非那雄胺的患者)和女性患者的毛发数量均显著增加。在半侧对比研究中，治疗侧的毛发数量增幅明显高于安慰剂组。结论：使用脂肪干细胞条件培养液治疗脱发似乎非常有效，可能为头发再生提供一种新的治疗方法。
Objective: Adipose-derived stem cells secrete various growth factors that promote hair growth. This study examined the effects of adipose-derived stem cell-conditioned medium on alopecia. Methods: Adipose-derived stem cell-conditioned medium was intradermally injected in 22 patients (11 men and 11 women) with alopecia. Patients received treatment every 3 to 5 weeks for a total of 6 sessions. Hair numbers were counted using trichograms before and after treatment. A half-side comparison study was also performed in 10 patients (8 men and 2 women). Results: Hair numbers were significantly increased after treatment in both male (including those without finasteride administration) and female patients. In the half-side comparison study, the increase in hair numbers was significantly higher on the treatment side than on the placebo side. Conclusion: Treatment using adipose-derived stem cell-conditioned medium appears highly effective for alopecia and may represent a new therapy for hair regeneration.