Endogenous Reproductive Hormones and C-reactive Protein Across the Menstrual Cycle
Endogenous Reproductive Hormones and C-reactive Protein Across the Menstrual Cycle
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DOI：
10.1093/aje/kwr343
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发表时间：
2012-03-01
影响因子：
5
通讯作者：
Schisterman, Enrique F.
中科院分区：
文献类型：
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作者：
Gaskins, Audrey J.;Wilchesky, Machelle;Schisterman, Enrique F.
CRP是临床环境中最常用的急性期反应标志物之一，也是健康女性心血管风险的预测指标；然而，关于绝经前妇女的生理调节的数据很少。本研究的目的是在生物循环研究（2005-2007）中评估内源性生殖激素和CRP之间的关系。来自纽约西部的年龄在18-44岁的女性进行了长达2个月经周期的前瞻性随访（n = 259）。血清CRP、雌二醇、黄体酮、促黄体生成素和促卵泡激素水平每周期测量8次，由生育监测仪计时。CRP水平在整个周期内变化显著（P < 0.001）。与其他阶段相比，更多的女性在月经期间被归类为心血管疾病风险升高（CRP, bb0.3 mg/L） （12.3% vs. 7.4%; P < 0.001）。雌二醇增加10倍与CRP降低24.3%相关（95%可信区间：19.3,29.0）。黄体黄体酮升高10倍与CRP升高19.4%相关（95%可信区间：8.4,31.5）。这些结果支持了内源性雌二醇可能具有抗炎作用的假设，并强调了在育龄妇女月经周期阶段标准化CRP测量的必要性。
Creactive protein (CRP) is one of the most commonly used markers of acute phase reaction in clinical settings and predictors of cardiovascular risk in healthy women; however, data on its physiologic regulation in premenopausal women are sparse. The objective of this study was to evaluate the association between endogenous reproductive hormones and CRP in the BioCycle Study (2005-2007). Women aged 18-44 years from western New York were followed prospectively for up to 2 menstrual cycles (n = 259). Serum levels of CRP, estradiol, progesterone, luteinizing hormone, and follicle-stimulating hormone were measured up to 8 times per cycle, timed by fertility monitors. CRP levels varied significantly across the cycle (P < 0.001). More women were classified as being at elevated risk of cardiovascular disease (CRP, >3 mg/L) during menses compared with other phases (12.3% vs. 7.4%; P < 0.001). A 10-fold increase in estradiol was associated with a 24.3% decrease in CRP (95% confidence interval: 19.3, 29.0). A 10-fold increase in luteal progesterone was associated with a 19.4% increase in CRP (95% confidence interval: 8.4, 31.5). These results support the hypothesis that endogenous estradiol might have antiinflammatory effects and highlight the need for standardization of CRP measurement to menstrual cycle phase in reproductive-aged women.