Transmission of human immunodeficiency virus type 1 resistant to nevirapine and zidovudine
Transmission of human immunodeficiency virus type 1 resistant to nevirapine and zidovudine
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DOI：
10.1086/516487
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发表时间：
1997-06-01
影响因子：
6.4
通讯作者：
Cooper, DA
中科院分区：
文献类型：
--
作者：
Imrie, A;Beveridge, A;Cooper, DA
对非核苷类逆转录酶抑制剂奈韦拉平和核苷类似物齐多夫定耐药的人类免疫缺陷病毒1型（HIV-1）从一名同性恋男子传播给他的性伴侣。病毒源患者在其伴侣初次感染HIV前2.5年开始接受齐多夫定和奈韦拉平联合治疗。他接受了7个月的两种治疗，然后停止奈韦拉平治疗，继续接受齐多夫定单药治疗16个月。在其伴侣血清转化前6个月，他已停止齐多夫定治疗。在接受者的原发性HIV感染疾病发作后不久，对从两名患者中获得的主要和次要分离株进行分析，证实了病毒逆转录酶密码子70、98和181处的HIV-1变异突变体被传播。这是第一个记录在案的对两种抗逆转录病毒化合物具有耐药性的HIV-1传播病例。
Human immunodeficiency virus type 1 (HIV-1) resistant to the nonnucleoside reverse transcriptase inhibitor nevirapine and to the nucleoside analogue zidovudine was transmitted from a homosexual man to his sex partner. The virus source patient had commenced combination zidovudine and nevirapine therapy 2.5 years prior to his partner's primary HIV infection. He received both therapies for 7 months, then discontinued nevirapine treatment, continuing to receive zidovudine monotherapy for a further 16 months. He had ceased zidovudine therapy 6 months before the time of his partner's seroconversion. Analysis of major and minor isolates obtained from both patients soon after onset of the recipient's primary HIV infection illness confirmed that an HIV-1 variant mutant at codons 70, 98, and 181 of the viral reverse transcriptase was transmitted. This is the first documented case of transmission of HIV-1 resistant to two antiretroviral compounds.