Fragmentation of the rest-activity rhythm correlates with age-related cognitive deficits
Fragmentation of the rest-activity rhythm correlates with age-related cognitive deficits
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DOI：
10.1111/j.1365-2869.2008.00704.x
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发表时间：
2009-03-01
影响因子：
4.4
通讯作者：
Scherder, Erik J. A.
中科院分区：
文献类型：
--
作者：
Oosterman, Joukje M.;van Someren, Eus J. W.;Scherder, Erik J. A.
衰老会影响认知能力和睡眠-觉醒节奏。最近大量研究支持睡眠对健康年轻人认知能力的影响，这表明睡眠-觉醒节奏紊乱可能会导致“与年龄相关的”认知能力下降。然而，这种关系以前没有被广泛研究过。本研究整合了一系列标准化的认知测试，以调查144名年龄为69.5 +/- 8.5（平均+/- SD）的居家老年人的思维速度、记忆和执行功能与活动记录的睡眠-觉醒节律的关系。多元回归分析表明，睡眠-觉醒节律碎片化与三个认知域的部分相关（r分别= -0.16,-0.19和-0.16）是显著的。这些关联独立于年龄的主要影响，这意味着老年人的休息-活动节奏和认知表现之间存在独特的关系。
Aging affects both cognitive performance and the sleep-wake rhythm. The recent surge of studies that support a role of sleep for cognitive performance in healthy young adults suggests that disturbed sleep-wake rhythms may contribute to 'age-related' cognitive decline. This relationship has however not previously been extensively investigated. The present correlational study integrated a battery of standardized cognitive tests to investigate the association of mental speed, memory, and executive function with actigraphically recorded sleep-wake rhythms in 144 home-dwelling elderly participants aged 69.5 +/- 8.5 (mean +/- SD). Multiple regression analyses showed that the partial correlations of the fragmentation of the sleep-wake rhythm with each of the three cognitive domains (r = -0.16, -0.19, and -0.16 respectively) were significant. These associations were independent from main effects of age, implying that a unique relationship between the rest-activity rhythm and cognitive performance is present in elderly people.