Targeting Integrins in Cancer Nanomedicine: Applications in Cancer Diagnosis and Therapy
Targeting Integrins in Cancer Nanomedicine: Applications in Cancer Diagnosis and Therapy
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DOI：
10.3390/cancers11111783
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发表时间：
2019-11
期刊：
影响因子：
5.2
通讯作者：
Ping-Hsiu Wu;A. Opadele;Yasuhito Onodera;Jin-Min Nam
中科院分区：
文献类型：
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作者：
Ping-Hsiu Wu;A. Opadele;Yasuhito Onodera;Jin-Min Nam
由于纳米技术的进步，纳米材料（纳米材料）在癌症诊断和治疗中的应用已成为癌症研究的前沿领域。用生物配体修饰纳米材料表面是引导纳米材料特异性作用于癌细胞的主要策略。这些配体可以与细胞表面的特定受体结合，使纳米材料能够主动靶向癌细胞。整合素是调节细胞与其微环境之间通讯的细胞表面受体之一。几种整合素在多种类型的癌细胞和肿瘤微血管系统中过度表达，并在介导各种细胞事件中发挥作用。因此，用整合素特异性配体对纳米材料进行表面修饰不仅增加了其与癌细胞的结合亲和力，而且还通过整合素的细胞内运输增强了纳米材料的细胞摄取。此外，整合素特异性配体本身通过与整合素相互作用来干扰癌症迁移和侵袭，这一发现为癌症纳米医学的新治疗方法提供了新的方向。本文回顾了已用于癌症纳米医学的整合素特异性配体，并概述了涉及使用整合素靶向纳米材料的癌症诊断和治疗策略的最新进展。
Due to advancements in nanotechnology, the application of nanosized materials (nanomaterials) in cancer diagnostics and therapeutics has become a leading area in cancer research. The decoration of nanomaterial surfaces with biological ligands is a major strategy for directing the actions of nanomaterials specifically to cancer cells. These ligands can bind to specific receptors on the cell surface and enable nanomaterials to actively target cancer cells. Integrins are one of the cell surface receptors that regulate the communication between cells and their microenvironment. Several integrins are overexpressed in many types of cancer cells and the tumor microvasculature and function in the mediation of various cellular events. Therefore, the surface modification of nanomaterials with integrin-specific ligands not only increases their binding affinity to cancer cells but also enhances the cellular uptake of nanomaterials through the intracellular trafficking of integrins. Moreover, the integrin-specific ligands themselves interfere with cancer migration and invasion by interacting with integrins, and this finding provides a novel direction for new treatment approaches in cancer nanomedicine. This article reviews the integrin-specific ligands that have been used in cancer nanomedicine and provides an overview of the recent progress in cancer diagnostics and therapeutic strategies involving the use of integrin-targeted nanomaterials.