Effect of Transcranial Electrical Stimulation over the Posterior Parietal Cortex on Tactile Spatial Discrimination Performance
Effect of Transcranial Electrical Stimulation over the Posterior Parietal Cortex on Tactile Spatial Discrimination Performance
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经颅电刺激后顶叶皮层对触觉空间辨别能力的影响
DOI：
10.1016/j.neuroscience.2022.05.010
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发表时间：
2022
期刊：
影响因子：
3.3
通讯作者：
Onishi Hideaki
中科院分区：
文献类型：
--
作者：
Saito Kei;Otsuru Naofumi;Inukai Yasuto;Kojima Sho;Miyaguchi Shota;Nagasaka Kazuaki;Onishi Hideaki
顶内沟区是后顶叶皮层（PPC）的一部分，在用手指辨别物体形状中起着重要作用。经颅随机噪声刺激（tRNS）和阳极经颅脉冲电流刺激（tPCS）是广泛用于调节皮质区域神经活动的非侵入性策略。因此，我们研究了tRNS和阳极tPCS应用于左或右PPC对20名神经健康受试者的右手食指触觉辨别性能的影响。在实验1中递送tRNS（刺激频率0.1-640 Hz）或在实验2中递送阳极tPCS（脉冲宽度50 ms和脉冲间间隔5 ms）之前和之后立即执行光栅定向任务（GOT）。在右侧PPC上执行tRNS显著改善了GOT上的辨别性能。受试者被分为低基线和高基线表现组。在左侧PPC上进行tRNS显著降低了高性能组的GOT辨别性能。相比之下，阳极tPCS交付的PPC的左，右半球没有显着影响触觉GOT的歧视表现的右手。我们表明，经颅电刺激的PPC可能会改善触觉感知，但效果取决于刺激方式，参数，和受刺激的半球。
The intraparietal sulcus region, which is part of the posterior parietal cortex (PPC), has been shown to play an important role in discriminating object shapes using the fingers. Transcranial random noise stimulation (tRNS) and anodal transcranial pulsed current stimulation (tPCS) are noninvasive strategies widely used to modulate neural activity in cortical regions. Therefore, we investigated the effects of tRNS and anodal tPCS applied to left or right PPC on the tactile discrimination performance of the right index finger in 20 neurologically healthy subjects. A grating orientation task (GOT) was performed before and immediately after delivering tRNS (stimulus frequency 0.1–640 Hz) in Experiment 1 or anodal tPCS (pulse width 50 ms and inter-pulse interval 5 ms) in Experiment 2. Performing tRNS over the right PPC significantly improved discrimination performance on the GOT. Subjects were classified into low and high baseline performance groups. Conducting tRNS over the left PPC significantly reduced the GOT discrimination performance in the high-performance group. By contrast, anodal tPCS delivered to the PPC of the left and right hemispheres had no significant effect on the tactile GOT discrimination performance of the right hand. We show that transcranial electric stimulation over the PPC may improve tactile perception but the effect depends on stimulus modality, parameters, and on the stimulated hemisphere.