Efficient nanoheater operated in a biological window for photo-hyperthermia therapy.
Efficient nanoheater operated in a biological window for photo-hyperthermia therapy.
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DOI：
10.1364/boe.10.001935
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发表时间：
2019-03
影响因子：
3.4
通讯作者：
Ji Li;Li Xu;Kailei Lu;M. Shahzad;Jingrong Ren;Enming Zhao;Hanyang Li;Lu Liu
中科院分区：
文献类型：
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作者：
Ji Li;Li Xu;Kailei Lu;M. Shahzad;Jingrong Ren;Enming Zhao;Hanyang Li;Lu Liu
远程监测和调节小范围内的温度对热疗至关重要。在此，我们报道了~11 nm的NaErF4纳米晶体作为超小型纳米加热器，在生物应用中具有很高的安全性。在1530 nm的光子激发下，NaErF4的上转换强度比常规980 nm的泵浦源明显增强。在功率依赖性测量的基础上讨论了上转换机制。重要的是，NaErF4通过1530 nm泵浦的光热转换效率高达75%。有效的近红外发射，集中在~800 nm，因此在生物窗口内，用于温度反馈。这种高效的纳米加热器在可控光热治疗中的潜在应用也得到了证明。
Remotely monitoring and regulating temperature in a small area are of vital importance for hyperthermia therapy. Herein, we report ~11 nm NaErF4 nanocrystal as the ultra-small nanoheater, which is highly safe for biological applications. Under 1530 nm photon excitation, upconversion intensity of NaErF4 is significantly enhanced as compared to the conventionally used 980 nm pumping source. Upconversion mechanisms are discussed on the basis of power dependence measurements. Importantly, light-to-heat transformation efficiency of NaErF4 through 1530 nm pumping is determined as high as 75%. Efficient NIR emission, centered at ~800 nm and thus within the biological window, is used for the temperature feedback. The potential applications of this highly efficient nanoheater for controlled photo-hyperthermia treatments are also demonstrated.