Socioeconomic impact of influenza on healthy children and their families
Socioeconomic impact of influenza on healthy children and their families
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DOI：
10.1097/01.inf.0000092188.48726.e4
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发表时间：
2003-10-01
影响因子：
3.6
通讯作者：
Crovari, P
中科院分区：
文献类型：
--
作者：
Principi, N;Esposito, S;Crovari, P
背景最近的研究表明，流感在其他健康儿童中可能具有重要的临床意义。然而，由于缺乏流感样疾病的实验室确认，许多研究的解释是有限的。因此，很难得出结论，流感的社会经济影响是否证明所有儿童接种疫苗，无论年龄或潜在的慢性疾病。我们前瞻性地收集了2001年至2002年流感季节期间3771名14岁以下患有呼吸道感染症状前往急诊室或初级保健儿科医生就诊的儿童的数据。通过病毒培养或聚合酶链反应验证流感感染。我们还将303名6个月至5岁的儿童随机分为两组，一组在流感季节前接种流感疫苗（n = 202），另一组在流感季节前不接种疫苗（n = 101）。流感对参与调查的儿童及其家庭接触者的社会经济影响进行了评估。3771名儿童中有352名（9.3%）记录了流感。与流感阴性儿童相比，流感儿童发烧和缺课的持续时间更长（P < 0.0001）。此外，流感阳性儿童的家庭接触者中，就医次数、缺勤或缺课次数以及需要在家帮助照顾患病儿童的次数均较高（P < 0.0001）。流感疫苗接种显著降低了健康儿童及其未接种疫苗家庭成员的直接和间接流感相关费用。这项研究的结果支持在所有年龄段的健康儿童中更广泛地使用流感疫苗，以减少流感对社区的社会经济负担。
Background. Recent studies indicate that influenza can be clinically important in otherwise healthy children. However, the interpretation of many studies is limited because of lack of laboratory confirmation of influenza-like illnesses. Therefore it is difficult to conclude whether the socioeconomic impact of influenza justifies vaccinating all children regardless of age or underlying chronic disorders.Methods. We prospectively collected data from 3771 children younger than 14 years of age presenting to emergency departments or primary care pediatricians with symptoms of respiratory tract infection during the influenza season of 2001 to 2002. Influenza infections were verified by virus culture or polymerase chain reaction. We additionally randomized 303 children age 6 months to 5 years to receive either influenza vaccine (n = 202) or no vaccination (n = 101) before the influenza season. The socioeconomic impact of influenza was assessed for both the participating children and their household contacts.Results. Influenza was documented in 352 (9.3%) of the 3771 children. Compared with influenza-negative children, children with influenza had longer durations of fever and absenteeism from day care or school (P < 0.0001). Further the numbers of medical visits, missed work or school days and the need for help at home to care for the sick children were higher among the household contacts of influenza-positive children (P < 0.0001). Influenza vaccination reduced significantly the direct and indirect influenza-related costs in healthy children and their unvaccinated family members.Conclusions. The findings of this study support a wider use of influenza vaccine in healthy children of all ages to reduce the socioeconomic burden of influenza on the community.