Fibrinolytic therapy in bacterial endocarditis: experimental studies in dogs.
Fibrinolytic therapy in bacterial endocarditis: experimental studies in dogs.
复制标题
细菌性心内膜炎的纤溶治疗：狗的实验研究。
DOI：
10.1093/oxfordjournals.eurheartj.a062100
复制
发表时间：
1986
影响因子：
39.3
通讯作者：
S. G. Griffin
中科院分区：
文献类型：
--
作者：
H. Dewar;M. R. Jones;W. Barnes;S. G. Griffin
我们进行了一项调查，评估在标准青霉素治疗的基础上增加链激酶治疗对血链球菌引起的人工感染性心内膜炎的价值。在猪中可以诱导低级别感染，这与人的链球菌心内膜炎非常相似，但由于技术原因，该模型不能用于进一步的实验。在狗血链球菌心内膜炎的诱导产生更严重的疾病与短的自然历史。狗被分为两组，一组单独使用青霉素，另一组使用青霉素和链激酶。在为期五天的疗程中，每天两次注射一种酰基化的链激酶-纤溶酶原复合物，使植被的大小大大减少，治愈率可能更高，对瓣膜的损害也更小。几乎可以肯定是由于栓塞引起的脑梗塞，在链激酶治疗组中明显更大，但肾脏的情况并非如此。对某些细菌性心内膜炎，特别是心脏右侧的心内膜炎的可能治疗价值进行了讨论。
An investigation was undertaken to assess the value of adding streptokinase therapy to standard penicillin treatment of artificially induced infective endocarditis due to Streptococcus sanguis. In pigs a low-grade infection could be induced which closely simulated streptococcal endocarditis in man, but for technical reasons this model proved unsatisfactory for further experimentation. In dogs the induction of S. sanguis endocarditis produced a more severe illness with a short natural history. Dogs were divided into two groups, one treated with penicillin alone, the other with penicillin and streptokinase. A five-day course, in which twice daily injections of an acylated streptokinase-plasminogen complex were given, caused a substantial reduction in the size of vegetations and possibly a higher proportion of cures and less damage to the valves. Infarction of the brain, almost certainly due to embolism, was significantly greater in the streptokinase treated group, but the same was not true of the kidneys. The possible value of such treatment for certain kinds of bacterial endocarditis in man, especially in the right side of the heart, is discussed.