Cohort Profile Update: Africa Centre Demographic Information System (ACDIS) and population-based HIV survey.

Cohort Profile Update: Africa Centre Demographic Information System (ACDIS) and population-based HIV survey.
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DOI:
10.1093/ije/dyaa264
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发表时间:
2021-03-03
影响因子:
7.7
通讯作者:
Herbst K
Herbst K
中科院分区:
医学1区
文献类型:
--
作者:
Gareta D;Baisley K;Mngomezulu T;Smit T;Khoza T;Nxumalo S;Dreyer J;Dube S;Majozi N;Ording-Jesperson G;Ehlers E;Harling G;Shahmanesh M;Siedner M;Hanekom W;Herbst K

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ACDIS为我们理解艾滋病毒流行做出了重要贡献。然而,尽管抗逆转录病毒疗法的覆盖率大幅提高,艾滋病毒的发病率仍然很高。南非是全球艾滋病毒感染者人数最多的国家,2018年估计为770万人。在PIP地区,2011-2015年15- 24岁妇女的艾滋病毒感染率估计为6.2/100人年。[3]发病率最近有所下降,2014年至2017年,年轻女性的发病率明显下降。4此外,自最初的ACDIS队列启动以来,艾滋病毒预防情况发生了很大变化。抗逆转录病毒疗法的推广(2004年首次在监测地区推广)对艾滋病毒抗体阳性者的健康和预期寿命产生了重大影响。5然而,需要预防新的感染,以结束艾滋病毒的流行。有效的艾滋病毒预防将需要综合采取生物医学、行为和结构性干预措施,这些措施需要在人口一级进行检验。
ACDIS has made important contributions to our understanding of the HIV epidemic. However, despite significant increases in antiretroviral therapy (ART) coverage, HIV incidence remains high. South Africa has the largest number of people living with HIV worldwide, estimated at 7.7 million in 2018. In the PIP area, HIV incidence among women aged 15–24years in 2011–2015 was estimated at 6.2/100 person-years. 3 Incidence has declined more recently, with marked reductions between 2014 and 2017 among young women. 4Moreover, the HIV prevention landscape has changed considerably since the initiation of the original ACDIS cohort. The scale-up of ART (first rolled out in the surveillance area in 2004) has had a major impact on the health and life expectancy of HIV-positive individuals. 5 However, new infections need to be prevented to bring an end to the HIV pandemic. Effective HIV prevention will require a combination of biomedical, behavioural and structural interventions that will need to be tested at the population level.
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发表时间: 2017-12-13
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