Meta-Analysis on the Association between Brain-Derived Neurotrophic Factor Polymorphism rs6265 and Ischemic Stroke, Poststroke Depression
Meta-Analysis on the Association between Brain-Derived Neurotrophic Factor Polymorphism rs6265 and Ischemic Stroke, Poststroke Depression
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脑源性神经营养因子rs6265多态性与缺血性脑卒中、脑卒中后抑郁关系的Meta分析
DOI：
10.1016/j.jstrokecerebrovasdis.2018.01.010
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发表时间：
2018-06-01
影响因子：
2.5
通讯作者：
Feng, Zhong-Ping
中科院分区：
文献类型：
--
作者：
Bao, Mei-Hua;Zhu, Shu-Zhen;Feng, Zhong-Ping
背景：缺血性卒中是一种多因素神经系统损伤，在世界范围内可导致死亡和残疾。卒中后抑郁是卒中最重要的神经精神后果。脑源性神经营养因子是一种神经营养因子家族成员，在调节神经元存活和分化中起关键作用。研究发现脑源性神经营养因子基因（rs6265）多态性可能与缺血性脑卒中及卒中后抑郁风险相关。然而，结果是不确定和不一致的。研究方法：在本荟萃分析中，检索了数据库PubMed、Embase、科克伦对照试验中心、CNKI和中国生物医学文献数据库，检索时间截止至2017年7月9日。结果如下：7项研究（1287例病例和1032例对照）被纳入缺血性卒中的荟萃分析，5项研究（272例病例和503例对照）被纳入卒中后抑郁。结果表明，在纯合子和显性模型中，脑源性神经营养因子GG基因型与缺血性卒中风险显著降低相关（比值比分别为0.57和0.80）。未发现rs6265与卒中后抑郁的相关性。结论：脑源性神经营养因子rs6265可作为缺血性脑卒中易感性的预测因子。然而，由于研究之间的异质性和低样本量，应谨慎解释该荟萃分析的结果。rs6265与脑卒中后抑郁的相关性有待进一步研究，尤其是在大样本的白种人中。
Background: Ischemic stroke is a multifactorial neurologic injury that causes mortality and disability worldwide. Poststroke depression is the most important neuropsychiatric consequence of stroke. Brain-derived neurotrophic factor is a neurotrophin family member that plays key role in regulating neuron survival and differentiation. Studies found a polymorphism in brain-derived neurotrophic factor gene (rs6265) may associate with the ischemic stroke and poststroke depression risk. However, the results are inconclusive and inconsistent. Methods: In the present meta-analysis, the database PubMed, Embase, Cochrane Central Register of Controlled Trials, CNKI, and Chinese Biomedical Literature Database were searched until July 9, 2017. Results: Seven studies with 1287 cases and 1032 controls were included for the meta-analysis of ischemic stroke, and five studies with 272 cases and 503 controls were included for poststroke depression. The results indicated that the GG genotype of brain-derived neurotrophic factor is related to a significantly lower risk of ischemic stroke in the homozygous and dominant models (odds ratio =.57 and .80, respectively). No significant relation was found between rs6265 and poststroke depression. Conclusions: Thus, brain-derived neurotrophic factor rs6265 might be recommended as a predictor of susceptibility of ischemic stroke. However, the results of this meta-analysis should be interpreted with caution because of the heterogeneity between studies and low sample size. Further studies are needed to evaluate the associations between rs6265 and poststroke depression, especially in Caucasians, with large sample size.