Fatty infiltration of the minor salivary glands is a selective feature of aging but not Sjögren's syndrome.
Fatty infiltration of the minor salivary glands is a selective feature of aging but not Sjögren's syndrome.
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DOI：
10.1080/08916934.2017.1385776
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发表时间：
2017-12
期刊：
影响因子：
3.5
通讯作者：
Farris AD
中科院分区：
文献类型：
--
作者：
Leehan KM;Pezant NP;Rasmussen A;Grundahl K;Moore JS;Radfar L;Lewis DM;Stone DU;Lessard CJ;Rhodus NL;Segal BM;Kaufman CE;Scofield RH;Sivils KL;Montgomery C;Farris AD
确定原发性SS患者（pSS）小唾液腺（SG）脂肪浸润的存在并评估其程度，并与非干燥性SS患者（nSS）进行比较。对134例pSS（n= 72）或nSS（n = 62）受试者的次要SG活检样本进行成像。使用Image J（National Institutes of Health，Bethesda，MD，USA）测量每个腺体横截面（每个受试者n=4-6个横截面）的总面积和脂肪替代面积。观察者对受试者分类状态不知情。通过逻辑回归和一般线性化模型（GLM）评价每例受试者计算的平均脂肪浸润面积，以评估脂肪浸润与临床检查结果、纤维化程度和年龄之间的关系。pSS受试者的平均脂肪浸润面积（中位数%（范围）4.97（0.05-30.2））与nSS受试者的平均脂肪浸润面积（3.75（0.087-41.9））无显著差异。浸润严重程度差异很大，脂肪替代大于6%的受试者在pSS和nSS受试者之间分布相等（χ2 p=0.50）。年龄解释了脂肪浸润和纤维化或唾液流量减少之间的所有明显关系。用于预测pSS与非SS分类（包括纤维化、年龄、脂肪替代和病灶评分）的全包GLM与任何去饱和模型均无显著差异。在没有迭代的模型中，脂肪替代对预测pSS分类的能力产生显著影响。脂肪浸润是一种与年龄相关的现象，而不是干燥综合征的选择性特征。不符合pSS标准的Sicca患者的小SG脂肪浸润率相似。
Determine the presence and assess the extent of fatty infiltration of the minor salivary glands (SG) of primary SS patients (pSS) as compared to those with non SS sicca (nSS). Minor SG biopsy samples from 134 subjects with pSS (n= 72) or nSS (n = 62) were imaged. Total area and fatty replacement area for each glandular cross-section (n=4–6 cross-sections per subject) were measured using Image J (National Institutes of Health, Bethesda, MD, USA). The observer was blinded to subject classification status. The average area of fatty infiltration calculated per subject was evaluated by logistic regression and general linearized models (GLM) to assess relationships between fatty infiltration and clinical exam results, extent of fibrosis and age. The average area of fatty infiltration for subjects with pSS (median% (range) 4.97 (0.05–30.2)) was not significantly different from that of those with nSS (3.75 (0.087–41.9). Infiltration severity varied widely, and subjects with fatty replacement greater than 6% were equivalently distributed between pSS and nSS participants (χ2 p=0.50). Age accounted for all apparent relationships between fatty infiltration and fibrosis or reduced saliva flow. The all-inclusive GLM for prediction of pSS versus non-SS classification including fibrosis, age, fatty replacement and focus score was not significantly different from any desaturated model. In no iteration of the model did fatty replacement exert a significant effect on the capacity to predict pSS classification. Fatty infiltration is an age-associated phenomenon and not a selective feature of Sjögren’s syndrome. Sicca patients who do not fulfill pSS criteria have similar rates of fatty infiltration of the minor SG.
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影响因子：
--
作者：
Katsiougiannis, Stergios;Kapsogeorgou, Efstathia K.;Skopouli, Fotini N.
通讯作者：
Skopouli, Fotini N.
DOI：
10.1016/0030-4220(74)90417-4
发表时间：
1974-01-01
期刊：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
影响因子：
--
作者：
GREENSPAN, JS;DANIELS, TE;SYLVESTER, RA
通讯作者：
SYLVESTER, RA
影响因子：
2.6
作者：
Carubbi, F.;Alunno, A.;Giacomelli, R.
通讯作者：
Giacomelli, R.
影响因子：
30.8
作者：
Li, Yongzhe;Zhang, Kunlin;Zhang, Fengchun
通讯作者：
Zhang, Fengchun
影响因子：
3.7
作者：
Konsta OD;Thabet Y;Le Dantec C;Brooks WH;Tzioufas AG;Pers JO;Renaudineau Y
通讯作者：
Renaudineau Y