Adiponectin Level as a Consequence of Genetic Variation, but Not Leptin Level or Leptin Adiponectin Ratio, Is a Risk Factor for Carotid Intima-Media Thickness
Adiponectin Level as a Consequence of Genetic Variation, but Not Leptin Level or Leptin Adiponectin Ratio, Is a Risk Factor for Carotid Intima-Media Thickness
复制标题
DOI：
10.1161/strokeaha.110.602375
复制
发表时间：
2011-06-01
期刊：
影响因子：
8.3
通讯作者：
Markus, Hugh S.
中科院分区：
文献类型：
--
作者：
Bevan, Steve;Meidtner, Karina;Markus, Hugh S.
背景和目的：脂联素和瘦素被认为是心血管疾病的危险因素，包括中风，通过动脉粥样硬化起作用。然而，研究在动力不足的队列中提供了相互矛盾的结果，一些研究表明瘦素：脂联素比值是一个更好的风险预测因子。我们研究了这些与颈动脉内膜中层厚度（IMT）的相关性，IMT是早期动脉粥样硬化和动脉重塑的标志物，也是卒中的独立预测因子。我们还研究了瘦素和脂联素基因和IMT的遗传变异之间的关联。方法脂联素和瘦素水平测定990个人从社区颈动脉粥样硬化进展研究。对编码脂联素的基因中的5个变体和编码瘦素的基因中的7个变体进行基因分型，并评估它们对循环水平的影响。结果脂联素水平与IMT呈负相关（-0.079，P =0.013）。瘦素水平和瘦素/脂联素比值与IMT无相关性。编码脂联素的ADIPOQ基因中的两种变体与脂联素水平改变相关，其中1种（rs 266729）与IMT相关。也有一个相互作用与体重指数（P=0.019）的关联存在于肥胖subjects（P=0.02）。结论-我们的研究结果支持脂联素在早期颈动脉IMT的因果作用，并建议它可能通过与肥胖的相互作用。相比之下，我们没有发现瘦素的作用的证据，也没有证据表明瘦素：脂联素的比例是一个更好的预测风险，脂联素水平单独。（中风。2011;42：1510-1514.）
Background and Purpose-The adipocytokines adiponectin and leptin have been suggested as risk factors for cardiovascular disease, including stroke, acting through atherosclerosis. However, studies have provided conflicting results in underpowered cohorts with some suggesting that the leptin: adiponectin ratio is a better predictor of risk. We examined these associations with carotid intima-media thickness (IMT), a marker of early atherosclerosis and arterial remodeling and an independent predictor of stroke. We also examined association between genetic variants in the leptin and adiponectin genes and IMT.Methods-Adiponectin and leptin levels were determined in 990 individuals from the community Carotid Atherosclerosis Progression Study. Five variants in the gene encoding adiponectin and 7 in the gene encoding leptin were genotyped and their effects on circulating levels assessed. Both were then correlated with IMT.Results-Adiponectin levels negatively correlated with IMT (-0.079, P=0.013). There was no correlation between leptin levels or leptin: adiponectin ratio and IMT. Two variants in the ADIPOQ gene encoding adiponectin were associated with altered adiponectin levels, 1 of which (rs266729) was associated with IMT. There was also an interaction with body mass index (P=0.019) with the association being present in obese subjects (P=0.02).Conclusions-Our results support a causal role for adiponectin in early carotid IMT and suggest it may act through interaction with obesity. In contrast, we found no evidence of a role for leptin and no evidence that leptin: adiponectin ratio is a better predictor of risk that adiponectin levels alone. (Stroke. 2011;42:1510-1514.)