The malaria merozoite, forty years on

The malaria merozoite, forty years on
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DOI:
10.1017/s0031182009990734
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发表时间:
2009-10-01
期刊:
影响因子:
2.4
通讯作者:
Mitchell, G. H.
Mitchell, G. H.
中科院分区:
医学2区
文献类型:
--
作者:
Bannister, L. H.;Mitchell, G. H.

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疟疾寄生虫的侵入性血液阶段,裂殖子,是专门用于捕获和进入红细胞的复杂实体。在过去的40年里,它们在疫苗接种和其他抗疟疾策略方面的潜力吸引了大量的研究关注,现在有相当多的数据与它们的生物学有关。在这篇文章中,我们将回顾这一时期的主要进展和仍然存在的挑战。
The invasive blood stage of malaria parasites, merozoites, are complex entities specialized for the capture and entry of red blood cells. Their potential for vaccination and other anti-malaria strategies have attracted much research attention over the last 40 years, and there is now a considerable body of data relating to their biology. In this article settle of the major advances over this period and remaining challenges are reviewed.