A novel, broad-spectrum anticancer compound containing the imidazo[4,5-e][1,3]diazepine ring system.
A novel, broad-spectrum anticancer compound containing the imidazo[4,5-e][1,3]diazepine ring system.
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一种新型广谱抗癌化合物，含有咪唑并[4,5-e][1,3]二氮杂环系统。
DOI：
10.1016/j.bmcl.2010.06.061
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发表时间：
2010
影响因子：
2.7
通讯作者：
Hosmane,RamachandraS
中科院分区：
文献类型：
--
作者：
Xie,Min;Ujjinamatada,RaviK;Sadowska,Mariola;Lapidus,RenaG;Edelman,MartinJ;Hosmane,RamachandraS
本文报道了一种新型咪唑并[4，5-e][1，3]二氮杂环化合物1的合成及其广谱抗癌活性。该化合物显示出有效的体外抗肿瘤活性，对测试的前列腺癌、肺癌、乳腺癌和卵巢癌细胞系具有低微摩尔IC 50。与1的杂环的六位连接的长烷基链似乎是观察到的生物活性所必需的。
Synthesis and broad-spectrum anticancer activity of a novel heterocyclic compound 1 containing the title imidazo[4,5-e][1,3]diazepine ring system have been reported. The compound shows potent in vitro antitumor activity with low micromolar IC50’s against prostate, lung, breast, and ovarian cancer cell lines tested. The long alkyl chain attached to the six-position of the heterocyclic ring of 1 appears to be necessary for the observed biological activity.