Sample size for a phylogenetic inference.
Sample size for a phylogenetic inference.
复制标题
用于系统发育推断的样本量。
DOI：
--
复制
发表时间：
1992
影响因子：
10.7
通讯作者：
William C. Navidi
中科院分区：
文献类型：
--
作者：
Gary A. Churchill;A. Haeseler;William C. Navidi
这项工作的目的是描述用于推断无根四物种系统发育中非零中心分支长度的样本大小计算。注意力仅限于独立的二进制字符，例如可以从核酸分子的嘌呤-嘧啶序列的比对中获得。描述了基于多项式模型的字符状态配置的统计测试。证明了在序列变化模型中包含不变位点的重要性，并量化了它们对样本量的影响。该方法适用于源自两种古细菌、一种真细菌和一种真核生物的小亚基 rRNA 序列的四物种比对。我们得出的结论是，这些序列中的信息不足以解析这棵树的分支顺序。给出了提供相当有效的测试所需的比对核苷酸位置数量的估计。
The objective of this work is to describe sample-size calculations for the inference of a nonzero central branch length in an unrooted four-species phylogeny. Attention is restricted to independent binary characters, such as might be obtained from an alignment of the purine-pyrimidine sequences of a nucleic acid molecule. A statistical test based on a multinomial model for character-state configurations is described. The importance of including invariable sites in models for sequence change is demonstrated, and their effect on sample size is quantified. The methods are applied to a four-species alignment of small-subunit rRNA sequences derived from two archaebacteria, a eubacteria and a eukaryote. We conclude that the information in these sequences is not sufficient to resolve the branching order of this tree. Estimates of the number of aligned nucleotide positions required to provide a reasonably powerful test are given.