PENETRATION OF BRAIN AND BRAIN TUMOR .7. TUMOR-BINDING SULFHYDRYL BORON COMPOUNDS
PENETRATION OF BRAIN AND BRAIN TUMOR .7. TUMOR-BINDING SULFHYDRYL BORON COMPOUNDS
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DOI：
10.1021/jm00316a042
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发表时间：
1967-01-01
影响因子：
7.3
通讯作者：
DAVIS, MA
中科院分区：
文献类型：
--
作者：
SOLOWAY, AH;HATANAKA, H;DAVIS, MA
发现了一类含巯基的硼化合物，可以固定在肿瘤组织和血清蛋白上。比较了B12H122-和B12H11SH2-的毒性和组织结合特性。有明确的迹象表明，这些阴离子上的SH基团是强效亲核试剂。本文还讨论了后一种阴离子对家兔的毒性研究。
The discovery of a class of boron compounds, containing the sulfhydryl group, which become fixed to tumor tissue and to serum proteins is presented. A comparison is made between the toxicity and tissue-binding properties of B12H122- and B12H11SH2-. There are definite indications that SH groups on such anions are potent nucleophiles. Toxicity studies of this latter anion in rabbits are also discussed.