Novobiocin-induced anti-proliferative and differentiating effects in melanoma B16.
Novobiocin-induced anti-proliferative and differentiating effects in melanoma B16.
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新生霉素诱导的黑色素瘤 B16 的抗增殖和分化作用。
DOI：
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发表时间：
1992
影响因子：
8.8
通讯作者：
Yechezkel Sidi
中科院分区：
文献类型：
--
作者：
J. Nordenberg;D. Albukrek;T. Hadar;A. Fux;Lina Wasserman;Abraham Novogrodsky;Yechezkel Sidi
在B16黑色素瘤细胞中评估了抗生素药物新生霉素的抗肿瘤特性。新生霉素显示出抑制黑素瘤B16细胞增殖。从培养基中去除新生霉素后，抗增殖作用逐渐可逆。新生霉素的生长抑制伴随着表型改变，包括形态学变化，脂质蓄积和显着增加的NADPH细胞色素c还原酶和γ谷氨酰转肽酶的活动。对植入B16黑色素瘤细胞的小鼠重复腹膜内给予新生霉素导致生长迟缓。在细胞生长测定中检查用新生霉素和其它化学分化诱导剂组合处理B16黑素瘤细胞。新生霉素和丁酸钠抑制细胞生长在一个近加性的方式，而新生霉素与GTP消耗剂，噻唑弗林或霉酚酸的组合导致在细胞生长的协同减少。我们的研究结果进一步支持新生霉素和其他分化剂可能在黑色素瘤治疗中具有潜在价值的论点。
The antibiotic drug novobiocin was evaluated for its anti-tumour properties in B16 melanoma cells. Novobiocin is shown to inhibit melanoma B16 cell proliferation. The anti-proliferative effect was gradually reversible upon removal of novobiocin from the culture medium. Growth inhibition by novobiocin was accompanied by phenotypic alterations, that included morphological changes, lipid accumulation and marked increases in the activities of NADPH cytochrome c reductase and gamma glutamyl transpeptidase. In vivo administration of repeated i.p. doses of novobiocin, to mice implanted with B16 melanoma cells resulted in growth retardation. The combined treatment of the B16 melanoma cells with novobiocin and other chemical inducers of differentiation was examined in a cell growth assay. Novobiocin and sodium butyrate inhibited cell growth in a near additive manner, while combination of novobiocin with the GTP-depleting agents, tiazofurin or mycophenolic acid resulted in a synergistic decrease in cell growth. Our results support the contention further that novobiocin and other differentiating agents might be of potential value in melanoma therapy.
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影响因子：
11.2
作者：
J. Sokoloski;G. Beardsley;A. Sartorelli
通讯作者：
J. Sokoloski;G. Beardsley;A. Sartorelli
噻唑呋林抑制 IMP 脱氢酶活性的临床和分子影响。
DOI：
10.1016/0065-2571(89)90080-0
发表时间：
1989
期刊：
Advances in enzyme regulation
影响因子：
--
作者：
Weber,G;Yamaji,Y;Olah,E;Natsumeda,Y;Jayaram,HN;Lapis,E;Zhen,WN;Prajda,N;Hoffman,R;Tricot,GJ
通讯作者：
Tricot,GJ
新生霉素和佛波醇 12-肉豆蔻酸酯-13-乙酸酯诱导的人类白血病细胞分化与拓扑异构酶 II 活性降低相关。
影响因子：
11.2
作者：
Constantinou,A;Henning-Chubb,C;Huberman,E
通讯作者：
Huberman,E
新生霉素对三种烷化剂的抗肿瘤活性以及肿瘤细胞和骨髓存活的影响。
影响因子：
11.2
作者：
Eder,JP;Teicher,BA;Holden,SA;Cathcart,KN;Schnipper,LE;Frei3rd,E
通讯作者：
Frei3rd,E
Novobiocin 在小鼠模型中增强烷化剂的细胞毒性和 DNA 链间交联。
DOI：
10.1172/jci112983
发表时间：
1987
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Eder,JP;Teicher,BA;Holden,SA;Cathcart,KN;Schnipper,LE
通讯作者：
Schnipper,LE