Epidermal growth factor receptor antagonists: Novel therapy for the treatment of high-grade gliomas
Epidermal growth factor receptor antagonists: Novel therapy for the treatment of high-grade gliomas
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DOI：
10.1227/01.neu.0000125006.88478.f6
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发表时间：
2004-06-01
期刊：
影响因子：
4.8
通讯作者：
Vogelbaum, MA
中科院分区：
文献类型：
--
作者：
Nathoo, N;Vogelbaum, MA
表皮生长因子受体（EGFR）信号的过度激活已被认为是多种上皮源性癌症发病和进展的重要步骤。这一知识导致了对针对EGFR信号转导途径关键成分的新型抗癌疗法的兴趣激增。最近已经开发了几种分子策略来调节EGFR或细胞表面受体以外的下游信号。异常EGFR信号在恶性胶质瘤进展中的重要作用使得EGFR靶向治疗在这种形式的癌症中特别有趣。使用抗egfr疗法治疗恶性脑肿瘤，虽然还处于起步阶段，但有望产生令人兴奋的结果，因为这些新药可能会增强现有疗法的有效性。
OVERACTIVATION OF EPIDERMAL growth factor receptor (EGFR) signaling has been recognized as an important step in the pathogenesis and progression of multiple forms of cancer of epithelial origin. This knowledge has led to a surge of interest in novel anticancer therapies targeting key constituents of the EGFR signal transduction pathway. Several molecular strategies have been developed recently to modulate either EGFR or the downstream signal beyond the cell surface receptor. The important role of aberrant EGFR signaling in the progression of malignant gliomas makes EGFR-targeted therapies of particular interest in this form of cancer. The use of anti-EGFR therapies against malignant brain tumors, although in its infancy, promises to yield although in its infancy therapy exciting results as these new drugs probably will enhance the usefulness of existing therapies.