Association of Sedentary Behavior and Physical Activity With Hyperuricemia and Sex Differences: Results From the China Multi-Ethnic Cohort Study
Association of Sedentary Behavior and Physical Activity With Hyperuricemia and Sex Differences: Results From the China Multi-Ethnic Cohort Study
复制标题
久坐行为和体力活动与高尿酸血症和性别差异的关联：中国多民族队列研究的结果
DOI：
10.3899/jrheum.211180
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发表时间：
2022-05-01
影响因子：
3.9
通讯作者：
Yin, Jianzhong
中科院分区：
文献类型：
--
作者：
Hong, Rudan;Huang, Juan;Yin, Jianzhong
目标。[目的]探讨中国多民族人群体力活动(PA)、久坐时间(ST；休闲和总ST)、通勤方式与高尿酸血症的关系，并分析其性别差异。方法：研究方法。基线数据来自云南地区中国多民族队列研究的22,094名参与者中国。通过问卷调查，对PA和久坐行为进行评估。高尿酸血症男性定义为血尿酸7.0 mg/dL，女性定义为6.0 mg/dL。建立了限制三次样条法(RCS)来模拟PA和ST与高尿酸血症之间可能的非线性关系。用Logistic回归估计优势比(OR)和95%可信区间。结果。调查人群高尿酸血症患病率为15.5%，其中男性25.5%，女性10.7%。与轻度PA的参与者相比，中度到重度PA的参与者患高尿酸血症的几率较低(调整后的OR值分别为0.85[95%CI 0.77-0.94]和0.88[95%CI 0.79-0.97])。而RCS显示PA与高尿酸血症呈U型非线性关系，高尿酸血症患病率与ST段升高呈线性关系。每天总ST>；=4小时会增加女性患高尿酸血症的风险，但对男性没有影响。交通方式显示，久坐行为增加了患高尿酸血症的风险，但基于性别的结果不一致。结论。适度的PA可能更有利于降低高尿酸血症的风险。降低ST对预防女性高尿酸血症的作用可能比男性更大。
Objective. To determine the association of physical activity (PA) and sedentary time (ST; leisure and total ST), commuting mode with hyperuricemia in a multiethnic Chinese population, and to analyze the difference between sexes. Methods. Baseline data were analyzed from 22,094 participants from the China Multi-Ethnic Cohort study in the Yunnan region, China. PA and sedentary behavior were assessed through questionnaires. Hyperuricemia was defined as serum urate > 7.0 mg/dL among men and > 6.0 mg/dL among women. A restricted cubic spline (RCS) was created to model the possible nonlinear relationship of PA and ST with hyperuricemia. Logistic regression was used to estimate the odds ratio (OR) and 95% CI. Results. Hyperuricemia prevalence in the observed population was 15.5% (men 25.5%, women 10.7%). Compared to those with light PA, participants with moderate-to-vigorous PA had lower odds of hyperuricemia (adjusted ORs were 0.85 [95% CI 0.77-0.94] and 0.88 [95% CI 0.79-0.97]). However, RCS showed a U-shaped nonlinear relationship between PA and hyperuricemia, and a linear relationship between hyperuricemia prevalence and increasing ST. Total ST >= 4 hours/day increased the risk of hyperuricemia in women but not in men. Mode of transportation revealed that sedentary behavior increased the risk of hyperuricemia, but there were inconsistent results based on sex. Conclusion. Moderate PA may be more beneficial in reducing the risk of hyperuricemia. Reducing ST may have a greater effect on preventing hyperuricemia in females than in males.