Pediatric cancer, posttraumatic stress and fear-related neural circuitry.
Pediatric cancer, posttraumatic stress and fear-related neural circuitry.
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DOI：
10.2217/ijh-2019-0002
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发表时间：
2019-07-11
影响因子：
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通讯作者：
Rabinak, Christine A
中科院分区：
文献类型：
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作者：
Marusak, Hilary A;Harper, Felicity W;Rabinak, Christine A
本文综述了儿童癌症相关创伤后应激症状（PTSS）的神经生物学效应。我们首先考虑儿童癌症相关PTSS的患病率和预测因素的研究，并将这些研究与典型发展中国家的研究进行比较（即，非癌症）人群。然后，我们简要介绍了PTSS涉及的大脑区域，并回顾了神经影像学研究在非癌症人群中检查PTSS的神经相关性。接下来，我们提出了一个框架和建议，为未来的研究。特别是，需要同时评估PTSS和神经影像学，以及社会人口学，医学，家庭因素和其他生活事件，以揭示导致癌症相关PTSS的机制。我们回顾了儿童癌症的神经影像学研究结果，以及最近一项关于癌症相关PTSS的研究，作为这一研究的起点。
This review examines the neurobiological effects of pediatric cancer-related posttraumatic stress symptoms (PTSS). We first consider studies on prevalence and predictors of childhood cancer-related PTSS and compare these studies to those in typically developing (i.e., noncancer) populations. Then, we briefly introduce the brain regions implicated in PTSS and review neuroimaging studies examining the neural correlates of PTSS in noncancer populations. Next, we present a framework and recommendations for future research. In particular, concurrent evaluation of PTSS and neuroimaging, as well as sociodemographic, medical, family factors, and other life events, are needed to uncover mechanisms leading to cancer-related PTSS. We review findings from neuroimaging studies on childhood cancer and one recent study on cancer-related PTSS as a starting point in this line of research.