Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information.
Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information.
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2016年治疗靶点数据库更新：丰富的临床药物靶点资源和靶向途径信息
DOI：
10.1093/nar/gkv1230
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发表时间：
2016-01-04
影响因子：
14.9
通讯作者：
Chen YZ
中科院分区：
文献类型：
--
作者：
Yang H;Qin C;Li YH;Tao L;Zhou J;Yu CY;Xu F;Chen Z;Zhu F;Chen YZ
广泛的药物发现工作已经产生了许多批准的和候选的药物，靶向不同生物途径中的各种靶标。几个可免费访问的数据库提供了药物、靶标和药物靶向途径信息，以促进药物发现工作，但临床试验药物和药物靶向途径的覆盖面不足。在这里，我们描述了一个更新的治疗靶点数据库（TTD）以前在NAR的功能。更新的内容包括：（i）大幅增加临床试验目标和药物的覆盖面（ii）大多数TTD靶标和药物条目与KEGG、MetaCyc/BioCyc、NetPath、PANTHER途径、途径相互作用数据库（PID）、PathWhiz、Reactome和WikiPathways的相应途径条目的交联，（iii）多个靶点和与这些途径中的每一个条目交联的药物的方便获取，以及（iv）最近出现的批准和研究药物。这一更新使TTD成为一个更有用的资源，以补充其他数据库，促进药物发现的努力。TTD可访问http://bidd.nus.edu.sg/group/ttd/ttd.asp。
Extensive drug discovery efforts have yielded many approved and candidate drugs targeting various targets in different biological pathways. Several freely accessible databases provide the drug, target and drug-targeted pathway information for facilitating drug discovery efforts, but there is an insufficient coverage of the clinical trial drugs and the drug-targeted pathways. Here, we describe an update of the Therapeutic Target Database (TTD) previously featured in NAR. The updated contents include: (i) significantly increased coverage of the clinical trial targets and drugs (1.6 and 2.3 times of the previous release, respectively), (ii) cross-links of most TTD target and drug entries to the corresponding pathway entries of KEGG, MetaCyc/BioCyc, NetPath, PANTHER pathway, Pathway Interaction Database (PID), PathWhiz, Reactome and WikiPathways, (iii) the convenient access of the multiple targets and drugs cross-linked to each of these pathway entries and (iv) the recently emerged approved and investigative drugs. This update makes TTD a more useful resource to complement other databases for facilitating the drug discovery efforts. TTD is accessible at http://bidd.nus.edu.sg/group/ttd/ttd.asp.