Lymphocytotoxic antibodies in patients with inflammatory bowel disease and their spouses--evidence for a transmissible agent.
Lymphocytotoxic antibodies in patients with inflammatory bowel disease and their spouses--evidence for a transmissible agent.
复制标题
炎症性肠病患者及其配偶的淋巴细胞毒性抗体——可传播病原体的证据。
DOI：
--
复制
发表时间：
1977
影响因子：
4.6
通讯作者：
R. Williams
中科院分区：
文献类型：
--
作者：
R. Strickland;W. C. Miller;N. Volpicelli;R. Gaeke;I. Wilson;J. Kirsner;R. Williams
检测了53例炎症性肠病（IBD）患者中的27例（51%）和他们53例（43%）未受影响的配偶中的23例（43%）的血清淋巴细胞毒性抗体（LCA）。与年龄和性别匹配的对照组（11%）或对照配偶（6%）相比，两组的LCA患病率均显著增加（P <0.001）。53对患者配偶中有16对（30%）LCA表达一致，而53对对照配偶中只有1对（2%）LCA表达一致（P <0.001）。与LCA结果相反，嗜异性抗体滴度在所有4个研究组中的分布相似。这表明，LCA可能代表传染性病原体在IBD的标志物，它们的发生在未受影响的密切接触者的患者可能表明这些代理人的传输给这些科目。
Serum lymphocytotoxic antibodies (LCA) were detected in twenty-seven out of fifty-three (51%) patients with inflammatory bowel disease (IBD) and in twenty-three out of their fifty-three (43%) unaffected spouses. The prevalence of LCA in both groups was significantly increased (P less than 0.001) compared to that in age- and sex-matched controls (11%) or in control spouses (6%). Concordant expression of LCA occurred in sixteen out of the fifty-three (30%) patient-spouse pairs compared to only one out of the fifty-three (2%) control-spouse pairs (P less than 0.001). In contrast to the LCA results, heterophile antibody titres were similarly distributed in all four study groups. It is suggested that LCA may represent markers of infectious agents in IBD and that their occurrence in unaffected close contacts of patients may indicate transmission of such agents to these subjects.