Portal vein-circulating tumor cells predict liver metastases in patients with resectable pancreatic cancer
Portal vein-circulating tumor cells predict liver metastases in patients with resectable pancreatic cancer
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DOI：
10.1007/s13277-014-2716-0
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发表时间：
2015-02-01
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影响因子：
--
通讯作者：
Braga, Marco
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文献类型：
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作者：
Bissolati, Massimiliano;Sandri, Maria Teresa;Braga, Marco
接受手术切除的胰腺癌患者往往在术后早期出现远处转移。在晚期胰腺癌患者中，循环肿瘤细胞(CTCs)的检测与较差的肿瘤预后相关。这项先导性研究的目的是探讨胰腺癌手术患者中CTCs的可能预后作用。20例胰腺切除术患者，术中分别从体循环(SC)和门静脉(PV)采集血样10mL。用CellSearchA(R)系统分析血液样本中的CTCs。所有患者每季度接受至少3年的肿瘤学随访。在9例(45%)患者中检测到CTC：5例仅在PV中有CTC，3例在SC和PV中都有CTC，1例仅在SC中。CTC阳性和CTC阴性的患者在人口统计学和癌症分期方面相似。CTC阳性患者和CTC阴性患者的总体生存率和无病生存率均无显著差异。在3年的随访中，门静脉癌阳性患者的肝转移率高于阴性患者(53%vs.8%，p=0.038)。45%的患者发现了CTCs。未发现CTCs与生存期之间的相关性。门静脉内CTCs的存在与术后较高的肝转移率有关。
Pancreatic cancer patients underwent surgical resection often present distant metastases early after surgery. Detection of circulating tumor cells (CTCs) has been correlated to a worse oncological outcome in patients with advanced pancreatic cancer. The objective of this pilot study is to investigate the possible prognostic role of CTCs in patients undergoing surgery for pancreatic cancer. In 20 patients undergoing pancreatic resection, 10 mL blood sample was collected intraoperatively from both systemic circulation (SC) and portal vein (PV). Blood sample was analyzed for CTCs with CellSearchA (R) system. All patients underwent an oncologic follow-up for at least 3 years, quarterly. CTCs were detected in nine (45 %) patients: five patients had CTCs in PV only, three patients in both SC and PV, and one patient in SC only. CTC-positive and CTC-negative patients were similar for demographics and cancer stage pattern. No significant differences were found in both overall and disease-free survival between CTC-positive and CTC-negative patients. At 3-year follow-up, portal vein CTC-positive patients presented a higher rate of liver metastases than CTC-negative patients (53 vs. 8 %, p = 0.038). CTCs were found in 45 % of the patients. No correlation between CTCs and survival was found. The presence of CTCs in portal vein has been associated to higher rate of liver metastases after surgery.