DIETARY RESTRICTION - EFFECTS ON RADIAL MAZE-LEARNING AND LIPOFUSCIN PIGMENT DEPOSITION IN THE HIPPOCAMPUS AND FRONTAL-CORTEX
DIETARY RESTRICTION - EFFECTS ON RADIAL MAZE-LEARNING AND LIPOFUSCIN PIGMENT DEPOSITION IN THE HIPPOCAMPUS AND FRONTAL-CORTEX
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DOI：
10.1016/0167-4943(87)90014-8
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发表时间：
1987-12-01
影响因子：
4
通讯作者：
NANDY, L
中科院分区：
文献类型：
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作者：
IDROBO, F;NANDY, K;NANDY, L
先前的研究表明，当早产儿和年轻的成年动物在营养充足的饮食中限制热量时，它们的寿命会延长，脑结构中的脂褐素沉积会减少。3个月大的C57BL/6小鼠接受12个月的热量限制（2 g/天），随后暴露于放射状迷宫学习范式。限制饮食组小鼠在径向迷宫任务中表现出更快的学习速度和更高的渐近表现，海马和额叶皮层神经元的脂褐素沉积也比自由喂养的对照组小鼠低。结果表明，饮食限制对径向迷宫学习有影响，这种改善的行为表现与海马和额叶皮层神经元脂褐素沉积的显著减少有关。
Previous studies have shown increased life span and decreased lipofuscin deposition in brain structures when both premature and young adult animals are calorically restricted of an otherwise nutritionally adequate diet. Three-months-old C57BL/6 mice were subjected to 12 months of caloric restriction (2 g/day), and subsequently exposed to a radial maze learning paradigm. Mice in the diet restriction group showed faster learning and higher asymptotic performance on the radial maze task, as well as lower lipofuscin deposition in the neurons of hippocampus and frontal cortex relative to control mice fed ad libitum. The results suggest that dietary restriction has effects on radial maze learning, and this improved behavioral performance was associated with significant reduction in lipofuscin pigment deposition in the neurons of hippocampus and frontal cortex.