Trace amine-associated receptor 1: A promising target for the treatment of psychostimulant addiction.
Trace amine-associated receptor 1: A promising target for the treatment of psychostimulant addiction.
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DOI：
10.1016/j.ejphar.2015.06.019
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发表时间：
2015-08-15
影响因子：
5
通讯作者：
Li JX
中科院分区：
文献类型：
--
作者：
Jing L;Li JX
精神兴奋剂的滥用和成瘾仍然是一个具有挑战性的临床问题，但没有有效的药物治疗。微量胺相关受体1（TAAR 1）作为一种新的药物靶点参与药物滥用的调节，已被越来越多的人所认识。本文就TAAR 1与多巴胺能系统之间的功能相互作用从电生理、生化到行为学方面的临床前证据进行了综述。TAAR 1基因敲除小鼠表现出对多巴胺能激活的敏感性增加，而TAAR 1激动剂降低可卡因和安非他明的神经化学作用，减弱可卡因和甲基安非他明的滥用和成瘾相关行为作用。结论TAAR 1激活在功能上调节多巴胺能活性，TAAR 1激动剂似乎是有前途的抗精神兴奋剂成瘾的药物治疗。
Abuse of and addiction to psychostimulants remains a challenging clinical issue, yet no effective pharmacotherapy is available. Trace amine associated receptor 1 (TAAR 1) is increasingly recognized as a novel drug target that participates in the modulation of drug abuse. This review analyzed existing preclinical evidence from electrophysiological, biochemical to behavioral aspects regarding the functional interactions between TAAR 1 and dopaminergic system. TAAR 1 knockout mice demonstrate increased sensitivity to dopaminergic activation while TAAR 1 agonists reduce the neurochemical effects of cocaine and amphetamines, attenuate abuse- and addiction-related behavioral effects of cocaine and methamphetamine. It is concluded that TAAR 1 activation functionally modulate the dopaminergic activity and TAAR 1 agonists appear to be promising pharmacotherapies against psychostimulant addiction.