Association of serum eicosapentaenoic acid to arachidonic acid ratio with microalbuminuria in a population of community-dwelling Japanese
Association of serum eicosapentaenoic acid to arachidonic acid ratio with microalbuminuria in a population of community-dwelling Japanese
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DOI：
10.1016/j.atherosclerosis.2015.02.033
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发表时间：
2015-04-01
期刊：
影响因子：
5.3
通讯作者：
Fukumoto, Yoshihiro
中科院分区：
文献类型：
--
作者：
Fukami, Ako;Adachi, Hisashi;Fukumoto, Yoshihiro
背景：流行病学证据表明，增加摄入omega-3多不饱和脂肪酸可以预防动脉粥样硬化相关的心血管疾病。最近，血清二十碳五烯酸与花生四烯酸（EPA/AA）比值被报道为心血管事件的预测指标。因此，我们检测了血清EPA/AA比值与微量白蛋白尿之间的关系。方法：在日本乌库镇（渔区）进行体格检查的居民444人，其中男性174人，女性270人，平均年龄66.6±9.3岁。他们接受了血液检查，包括血清EPA和AA水平，以及尿液检查，以检查微量白蛋白尿。通过一份简短的自我管理饮食史问卷来评估饮食模式。微量白蛋白尿定义为尿白蛋白与肌酐比值(UACR) >= 30 mg/g cr。结果：男性EPA/AA比值均值为0.66 +/- 0.3，女性EPA/AA比值均值为0.51 +/- 0.2。多元逐步回归分析显示，收缩压（p < 0.0001）、高敏c反应蛋白（p < 0.01）、血清EPA/AA比（p < 0.01，负相关）和血红蛋白A(1c) （p < 0.05）与微量白蛋白尿显著相关。经混杂因素校正后，低EPA/AA组微量白蛋白尿患病率显著高于其他组（优势比为3.45,95%可信区间为1.47 ~ 8.13,p < 0.01）。结论：本研究表明血清EPA/AA比值与微量白蛋白尿密切相关。2015爱思唯尔爱尔兰有限公司版权所有。
Background: Epidemiological evidence suggests that the increased intake of omega-3 polyunsaturated fatty acids can prevent atherosclerosis-related cardiovascular diseases. Recently, serum eicosapentaenoic acid to arachidonic acid (EPA/AA) ratio has been reported to be a predictive marker of cardiovascular events. Accordingly, we examined the relationship between serum EPA/AA ratio and microalbuminuria.Methods: We enrolled 444 residents (174 males and 270 females, mean age 66.6 +/- 9.3 years) who underwent a physical examination in Uku town (fishing area) in Japan. They received blood tests including serum levels of EPA and AA, and urine test to examine microalbuminuria. Eating and drinking patterns were evaluated by a brief self-administered diet history questionnaire. Microalbuminuria was defined as a urinary albumin-to-creatinine ratio (UACR) >= 30 mg/g Cr.Results: The mean EPA/AA ratio was 0.66 +/- 0.3 in males and 0.51 +/- 0.2 in females. Multiple stepwise regression analyses revealed that systolic blood pressure (p < 0.0001), high sensitive C-reactive protein (p < 0.01), serum EPA/AA ratio (p < 0.01, inversely), and hemoglobin A(1c) (p < 0.05) were significantly associated with microalbuminuria. In the group with low serum EPA/AA ratio, the prevalence of microalbuminuria was significantly higher than the other, after the adjustments for confounding factors (odds ratio, 3.45; 95% confidence interval, 1.47-8.13; p < 0.01).Conclusion: The present study demonstrated that serum EPA/AA ratio was strongly associated with microalbuminuria. (C) 2015 Elsevier Ireland Ltd. All rights reserved.