Clinical and pathologic features of focal myositis
Clinical and pathologic features of focal myositis
复制标题
局灶性肌炎的临床和病理特征
作者：
A. Smith;S. Urbanits;M. Blaivas;W. Grisold;James W. Russell
为了明确局灶性肌炎（FM）的分科学，我们报告了8例以一块肌肉局灶性扩大为表现的患者的临床和病理特征。大多数患者在没有免疫抑制治疗的情况下得到改善，没有一例发生多发性肌炎。病理特征为炎症性肌病，伴有肌纤维肥大和中度至重度炎症。在大多数病例中，被厚纤维束包裹的紧密堆积的肌肉纤维簇与FM的诊断有关。免疫组化显示所有病例间质浸润均以T细胞为主。没有血管炎的迹象。我们的研究结果表明FM是一种良性疾病，具有一定的临床特征，将其与其他炎症性肌病区分开来。病理改变，如被厚纤维化包围的大簇嵌套肌纤维，比多发性肌炎更具有FM的特征。©2000 John Wiley & Sons, Inc肌肉神经23 (2):1569-1575
To clarify the nosology of focal myositis (FM), we report the clinical and pathologic features of eight patients presenting with focal enlargement of one muscle. Most patients improved without immunosuppressive therapy, and none developed polymyositis. Pathologic features were those of an inflammatory myopathy, with muscle fiber hypertrophy and moderate to severe inflammation. In most cases, a clustering of tightly packed muscle fibers, enveloped by a thick bundle of fibrosis, was associated with the diagnosis of FM. Immunohistochemistry showed T cell predominance within the interstitial infiltrates in all cases. No evidence of vasculitis was present. Our findings suggest that FM is a benign condition that has certain clinical features separating it from other inflammatory myopathies. Pathologic changes, such as large clusters of nesting muscle fibers surrounded by thick fibrosis, are more characteristic of FM than polymyositis. © 2000 John Wiley & Sons, Inc. Muscle Nerve 23: 1569–1575, 2000