Genomic approaches in Xanthomonas campestris pv. vesicatoria allow fishing for virulence genes
Genomic approaches in Xanthomonas campestris pv. vesicatoria allow fishing for virulence genes
复制标题
DOI：
10.1016/j.jbiotec.2003.07.012
复制
发表时间：
2003-12-19
影响因子：
4.1
通讯作者：
Bonas, U
中科院分区：
文献类型：
--
作者：
Büttner, D;Noël, L;Bonas, U
野油菜黄单胞菌 pv.囊泡菌是辣椒和番茄的一种重要的经济病原体，已被确立为研究细菌感染策略的模式生物。在过去的二十年中，深入的遗传和分子分析导致分离出许多在与宿主植物的密切分子关系中发挥作用的基因。致病性的关键是 III 型蛋白分泌系统，它将细菌效应蛋白输送到宿主细胞中。目前，X.campestris pv. 的基因组。 vesicatoria 正在测序。基因组序列信息的可用性将为通过生物信息学方法鉴定新的细菌毒力因子铺平道路。在本文中，我们将介绍基因组序列分析的初步数据，并描述鉴定细菌 III 型效应基因的最新研究和新颖研究。 (C) 2003 Elsevier B.V. 保留所有权利。
Xanthomonas campestris pv. vesicatoria is an economically important pathogen of pepper and tomato and has been established as a model organism to study bacterial infection strategies. In the last two decades, intensive genetic and molecular analyses led to the isolation of many genes that play a role in the intimate molecular relationship with the host plant. Essential for pathogenicity is a type III protein secretion system, which delivers bacterial effector proteins into the host cell. Currently, the genome of X. campestris pv. vesicatoria is being sequenced. The availability of genomic sequence information will pave the way for the identification of new bacterial virulence factors by bioinformatic approaches. In this article, we will present preliminary data from the genomic sequence analysis and describe recent and novel studies to identify bacterial type III effector genes. (C) 2003 Elsevier B.V. All rights reserved.