An essential role for ectodomain shedding in mammalian development
An essential role for ectodomain shedding in mammalian development
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DOI：
10.1126/science.282.5392.1281
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发表时间：
1998-11-13
期刊：
影响因子：
56.9
通讯作者：
Black, RA
中科院分区：
文献类型：
--
作者：
Peschon, JJ;Slack, JL;Black, RA
许多蛋白质的胞外结构域通过蛋白质分解从细胞中释放出来，从而产生可溶性的细胞间调节因子。只有在肿瘤坏死因子-α(TNF-α)被释放的情况下，才能确定负责的蛋白酶，即肿瘤坏死因子-a转换酶(TACE)。对缺乏这种金属蛋白酶-去整合素的细胞的分析表明，TACE在处理其他细胞表面蛋白方面的作用得到了扩大，包括肿瘤坏死因子受体、L-选择素黏附分子和转化生长因子-α。缺乏TACE的小鼠的表型表明，可溶性转化生长因子α在正常发育中起着至关重要的作用，并强调了体内蛋白质胞外结构域脱落的重要性。
The ectodomains of numerous proteins are released from cells by proteolysis to yield soluble intercellular regulators. The responsible protease, tumor necrosis factor-a converting enzyme (TACE), has been identified only in the case when tumor necrosis factor-alpha (TNF alpha) is released. Analyses of cells lacking this metalloproteinase-disintegrin revealed an expanded role for TACE in the processing of other cell surface proteins, including a TNF receptor, the L-selectin adhesion molecule, and transforming growth factor-alpha (TGF alpha). The phenotype of mice Lacking TACE suggests an essential role for soluble TGF alpha in normal development and emphasizes the importance of protein ectodomain shedding in vivo.