Mass spectrometry-based proteomics and peptidomics for biomarker discovery in neurodegenerative diseases.
Mass spectrometry-based proteomics and peptidomics for biomarker discovery in neurodegenerative diseases.
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发表时间：
2009
影响因子：
1.4
通讯作者：
Xin Wei;Lingjun Li
中科院分区：
文献类型：
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作者：
Xin Wei;Lingjun Li
There is an urgent need to search for biomarkers that are indicative of neurodegenerative diseases, as the clinical diagnosis of which remains unsatisfactory. Mass spectrometry (MS) has been playing an important role in studying peptide and protein identities, structures, modifications and interactions that collectively drive their biological functions. MS-based proteomics technology is thus well suited for the biomarker discovery. This article reviews the overall strategies and workflows employed for biomarker discovery and recent applications of MS-based proteomics in neurodegenerative diseases. Special emphasis is placed on the studies of protein post-translational modification pattern changes and differential peptidomics under these pathological conditions.
