Vitamin D levels and risk of delirium A mendelian randomization study in the UK Biobank
Vitamin D levels and risk of delirium A mendelian randomization study in the UK Biobank
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DOI：
10.1212/wnl.0000000000007136
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发表时间：
2019-03-19
期刊：
影响因子：
9.9
通讯作者：
Melzer, David
中科院分区：
文献类型：
--
作者：
Bowman, Kirsty;Jones, Lindsay;Melzer, David
目的 使用孟德尔随机模型中的遗传变异来评估维生素 D 水平对谵妄住院事件的影响，该模型可最大限度地减少混杂因素并排除反向因果关系。方法使用英国生物银行、基于社区的志愿者队列（2006-2010）进行纵向分析，并在 0.05 期间确定医院诊断的谵妄事件（ICD-10 F05）。具有 >= 1 APOE epsilon 4 等位基因的参与者更有可能发生谵妄（例如，与 epsilon 3 epsilon 3 相比，epsilon 4 epsilon 4 风险比 = 3.73，95% 置信区间 2.68-5.21，p = 8.0 x 10(-15)），但与维生素 D 变体没有相互作用。结论和相关性 在一个大型社区队列中，有遗传证据支持维生素 D 水平在谵妄事件中的因果作用。需要进行纠正低维生素 D 水平来预防谵妄的试验。
Objective To estimate effects of vitamin D levels on incident delirium hospital admissions using inherited genetic variants in mendelian randomization models, which minimize confounding and exclude reverse causation. Methods Longitudinal analysis using the UK Biobank, community-based, volunteer cohort (2006-2010) with incident hospital-diagnosed delirium (ICD-10 F05) ascertained during 0.05). Participants with >= 1 APOE epsilon 4 allele were more likely to develop delirium (e.g., epsilon 4 epsilon 4 hazard ratio = 3.73, 95% confidence interval 2.68-5.21, p = 8.0 x 10(-15) compared to epsilon 3 epsilon 3), but there was no interaction with vitamin D variants. Conclusions and relevance In a large community-based cohort, there is genetic evidence supporting a causal role for vitamin D levels in incident delirium. Trials of correction of low vitamin D levels in the prevention of delirium are needed.