Human centromedian-parafascicular complex signals sensory cues for goal-oriented behavior selection
Human centromedian-parafascicular complex signals sensory cues for goal-oriented behavior selection
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DOI：
10.1016/j.neuroimage.2017.03.019
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发表时间：
2017-05-15
期刊：
影响因子：
5.7
通讯作者：
Krauss, Joachim K.
中科院分区：
文献类型：
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作者：
Schepers, Inga M.;Beck, Anne-Kathrin;Krauss, Joachim K.
实验研究表明，板内丘脑的中央核-旁束复合体（CM-Pf）在注意定向和行为相关刺激的加工过程中被激活。这些观察结果导致了CM-Pf在目标导向行为选择中起关键作用的假设。我们在这里开始测试这一假设与患者的电生理记录植入电极在CM-Pf的脑深部电刺激（DBS）治疗慢性神经性疼痛。6名患者参与了（1）听觉三类古怪实验，需要按下按钮以达到目标音调，但不需要按下标准和异常音调;以及（2）多说话人实验，需要注意选择目标词，需要响应选择目标图像。受试者对目标音和目标词表现出短暂的神经反应（8-15 Hz）。另外，两名受试者对目标图像表现出短暂的神经反应（15-25 Hz）。所有的感觉目标刺激都与一个内部目标有关，需要一个行为选择（注意选择，反应选择）。在组分析中，神经反应更大的目标音调比偏差和标准的音调和目标词比其他任务相关的话，不需要注意选择。短暂的神经反应发生在目标刺激之后，但在明显的行为反应之前。我们的研究结果表明，在人类受试者的CM-Pf参与信号的感官输入相关的目标导向的行为选择。
Experimental research has shown that the centromedian-parafascicular complex (CM-Pf) of the intralaminar thalamus is activated in attentional orienting and processing of behaviorally relevant stimuli. These observations resulted in the hypothesis that the CM-Pf plays a pivotal role in goal-oriented behavior selection. We here set out to test this hypothesis with electrophysiological recordings from patients with electrodes implanted in CM-Pf for deep brain stimulation (DBS) treatment of chronic neuropathic pain. Six patients participated in (1) an auditory three-class oddball experiment, which required a button press to target tones, but not to standard and deviant tones and in (2) a multi-speaker experiment with a target word that required attention selection and a target image that required response selection. Subjects showed transient neural responses (8-15 Hz) to the target tone and the target word. Two subjects additionally showed transient neural responses (15-25 Hz) to the target image. All sensory target stimuli were related to an internal goal and required a behavior selection (attention selection, response selection). In group analyses, neural responses were greater to target tones than deviant and standard tones and to target words than other task-relevant words that did not require attention selection. The transient neural responses occurred after the target stimuli but prior to the overt behavioral response. Our results demonstrate that in human subjects the CM-Pf is involved in signaling sensory inputs related to goal-oriented selection of behavior.